Neurology
Conditions
Deep dives — MCAS: mediators & symptom map · testing · low-histamine diet · H1/H2 blocker stacks · cromolyn & ketotifen · triggers & flares · hereditary α-tryptasemia · natural stabilizers
Deep dives — ME/CFS: Post-Exertional Malaise (PEM) Explained · 2-Day CPET & Objective Testing · Pacing & Energy Envelope · IOM/SEID vs CCC vs ICC Criteria · Orthostatic Intolerance in ME/CFS · Post-Viral Triggers: EBV & Others · Severe & Very Severe ME · LDN, Abilify & Experimental Therapies
Deep dives — POTS: subtypes · tilt table test · salt & hydration · compression & exercise · medications · the POTS/MCAS/EDS triad · LDN · vagus nerve & retraining
Neurology focuses on disorders of the brain, spinal cord, and nervous system.
Interactive Visualization Nerve Impulse β fire an action potential Watch it race down the axon: sodium rushing in, potassium out, a live voltage trace spiking, and neurotransmitter crossing the synapse. Launch → Interactive Visualization The Reflex Arc β fire a reflex faster than thought Tap the tendon and watch the signal fire into the spinal cord and straight back out to the muscle in ~50 ms β while the brain only finds out afterward. Launch → Interactive Visualization Cerebrospinal Fluid β follow the brain's plumbing Make CSF at the choroid plexus and follow it around the brain and spine and back to the blood β block the aqueduct to flood the ventricles, or fall asleep and watch the glymphatic flush. Launch → Interactive Visualization The Neuromuscular Junction β fire a nerve at a muscle Fire a nerve and watch calcium dump acetylcholine across the gap to spark the muscle β then block it with Botox, strip the receptors in myasthenia gravis, or jam the off-switch with a nerve agent. Launch →
Key Research Papers
Foundational and recent peer-reviewed publications across the major neurology subspecialties — stroke, dementia, neurodegenerative disease, multiple sclerosis, epilepsy, headache, and movement disorders. Each citation links to the full text via DOI.
- The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue Plasminogen Activator for Acute Ischemic Stroke. New England Journal of Medicine. 1995;333(24):1581–1587. — doi:10.1056/NEJM199512143332401
- Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients with Acute Ischemic Stroke (AHA/ASA). Stroke. 2019;50(12):e344–e418. — doi:10.1161/STR.0000000000000211
- Berkhemer OA, Fransen PSS, Beumer D, et al. A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke (MR CLEAN). New England Journal of Medicine. 2015;372(1):11–20. — doi:10.1056/NEJMoa1411587
- Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus Warfarin in Patients with Atrial Fibrillation (RE-LY). New England Journal of Medicine. 2009;361(12):1139–1151. — doi:10.1056/NEJMoa0905561
- Granger CB, Alexander JH, McMurray JJV, et al. Apixaban versus Warfarin in Patients with Atrial Fibrillation (ARISTOTLE). New England Journal of Medicine. 2011;365(11):981–992. — doi:10.1056/NEJMoa1107039
- Sperling RA, Aisen PS, Beckett LA, et al. Toward Defining the Preclinical Stages of Alzheimer's Disease: Recommendations from the NIA-AA Workgroups on Diagnostic Guidelines for Alzheimer's Disease. Alzheimer's & Dementia. 2011;7(3):280–292. — doi:10.1016/j.jalz.2011.03.003
- Sims JR, Zimmer JA, Evans CD, et al. Donanemab in Early Symptomatic Alzheimer Disease (TRAILBLAZER-ALZ 2). JAMA. 2023;330(6):512–527. — doi:10.1001/jama.2023.13239
- van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in Early Alzheimer's Disease (CLARITY-AD). New England Journal of Medicine. 2023;388(1):9–21. — doi:10.1056/NEJMoa2212948
- Postuma RB, Berg D, Stern M, et al. MDS Clinical Diagnostic Criteria for Parkinson's Disease. Movement Disorders. 2015;30(12):1591–1601. — doi:10.1002/mds.26424
- Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria. Lancet Neurology. 2018;17(2):162–173. — doi:10.1016/S1474-4422(17)30470-2
- Hauser SL, Bar-Or A, Comi G, et al. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis (OPERA I and II). New England Journal of Medicine. 2017;376(3):221–234. — doi:10.1056/NEJMoa1601277
- Bensimon G, Lacomblez L, Meininger V. A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis. New England Journal of Medicine. 1994;330(9):585–591. — doi:10.1056/NEJM199403033300901
- Brown RH Jr, Al-Chalabi A. Amyotrophic Lateral Sclerosis. New England Journal of Medicine. 2017;377(2):162–172. — doi:10.1056/NEJMra1603471
- Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE Official Report: A Practical Clinical Definition of Epilepsy. Epilepsia. 2014;55(4):475–482. — doi:10.1111/epi.12550
- Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd Edition. Cephalalgia. 2018;38(1):1–211. — doi:10.1177/0333102417738202
- Goadsby PJ, Reuter U, Hallström Y, et al. A Controlled Trial of Erenumab for Episodic Migraine. New England Journal of Medicine. 2017;377(22):2123–2132. — doi:10.1056/NEJMoa1705848
PubMed Topic Searches
Live PubMed queries that update as new papers are indexed.
- PubMed: neurology clinical review
- PubMed: neurodegenerative disease mechanisms
- PubMed: Alzheimer's disease
- PubMed: Parkinson's disease
- PubMed: multiple sclerosis
- PubMed: epilepsy management
- PubMed: amyotrophic lateral sclerosis
- PubMed: Huntington's disease
- PubMed: peripheral neuropathy
- PubMed: myasthenia gravis
- PubMed: ME/CFS
- PubMed: POTS
Connections
- All Conditions
- The Neuromuscular Junction: How a Nerve Commands a Muscle — interactive animation
- Cerebrospinal Fluid: The Brainβs Cushion & Plumbing — interactive animation
- The Reflex Arc: Faster Than Thought — interactive animation
- Nerve Impulse — interactive animation
- Alzheimer's Disease
- Parkinson's Disease
- Multiple Sclerosis
- ALS
- Epilepsy
- Huntington's Disease
- Myasthenia Gravis
- Peripheral Neuropathy
- ME/CFS
- POTS
- MCAS
- Stroke
- TIA (Mini-Stroke)
- Guillain-BarrΓ© Syndrome
- Narcolepsy
- Tourette Syndrome
- Vascular Dementia
- Polio & Post-Polio Syndrome — paralytic polio, and the new weakness survivors can develop decades later
- O’Keefe & the Mosers (Nobel 2014) — place cells and grid cells, the brain’s positioning system, and what the London taxi-driver studies actually found
- Herbs covered on this site that discuss conditions in this specialty: Feverfew · Butterbur · Soursop Leaf (Annona muricata) · Wood Betony · Crape Jasmine (Tabernaemontana divaricata) · Jewel Vine (Derris elliptica)
All Neurology Articles A–Z
Every article in this specialty, listed alphabetically.
- Alzheimer's Disease
- Amyotrophic Lateral Sclerosis (ALS)
- Anti-LGI1 Encephalitis
- Anti-NMDA Receptor Encephalitis
- Becker Muscular Dystrophy (BMD)
- Bell's Palsy
- CADASIL β Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
- Cerebellar Ataxia
- Cerebral Venous Thrombosis
- Charcot-Marie-Tooth Disease (CMT)
- Chiari Malformation
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Circadian Rhythm Sleep-Wake Disorders
- Cluster Headache
- Concussion
- Corticobasal Syndrome (CBS)
- Creutzfeldt-Jakob Disease (CJD)
- Delirium
- Duchenne Muscular Dystrophy (DMD)
- Encephalitis
- Epilepsy
- Essential Tremor
- Facioscapulohumeral Muscular Dystrophy (FSHD)
- Friedreich's Ataxia
- Frontotemporal Dementia (FTD)
- Guillain-BarrΓ© Syndrome
- Hemifacial Spasm
- Huntington's Disease
- Idiopathic Intracranial Hypertension
- Kleine-Levin Syndrome
- Korsakoff Syndrome
- Lambert-Eaton Myasthenic Syndrome (LEMS)
- Lewy Body Dementia
- Mast Cell Activation Syndrome (MCAS): The Underdiagnosed Allergic-Autonomic Condition
- Migraine
- MOG Antibody Disease (MOGAD)
- Multiple Sclerosis (MS)
- Multiple System Atrophy
- Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS): An Under-Recognized Multi-System Disease
- Myasthenia Gravis
- Myotonic Dystrophy (DM1 and DM2)
- Narcolepsy
- Neuromyelitis Optica (NMOSD)
- Normal Pressure Hydrocephalus
- Parkinson's Disease
- Peripheral Neuropathy
- Posterior Reversible Encephalopathy Syndrome (PRES)
- Postural Orthostatic Tachycardia Syndrome (POTS): The Autonomic Syndrome Everyone Is Finally Talking About
- Prion Disease
- Progressive Supranuclear Palsy
- Restless Legs Syndrome (Willis-Ekbom Disease)
- Spinal Muscular Atrophy (SMA)
- Stiff-Person Syndrome
- Stroke — Ischemic and Hemorrhagic
- Subacute Combined Degeneration of the Spinal Cord
- Susac Syndrome
- TIA β Transient Ischemic Attack (Mini-Stroke)
- Tourette Syndrome
- Transverse Myelitis
- Traumatic Brain Injury (TBI)
- Trigeminal Neuralgia
- Vascular Dementia
- Wernicke's Encephalopathy
- Wernicke-Korsakoff Syndrome