Chronic Pain

What is Chronic Pain?

Chronic pain is pain that lasts for more than 3 to 6 months or beyond the normal healing time of an injury. It can persist even after the initial cause is resolved and may affect various parts of the body, impacting a person’s physical and mental health.

Causes of Chronic Pain

Types of Chronic Pain

1. Neuropathic Pain

2. Musculoskeletal Pain

3. Headaches and Migraines

4. Visceral Pain

Symptoms of Chronic Pain

Risk Factors

Diagnosis

Treatment Options

Prevention Strategies

Complications of Chronic Pain


References & Research

Historical Background

The modern understanding of chronic pain as a distinct disease entity was shaped by John Bonica, who founded the first multidisciplinary pain clinic in 1947 and published "The Management of Pain" in 1953. Ronald Melzack and Patrick Wall proposed the gate control theory of pain in 1965, revolutionizing pain science. The International Association for the Study of Pain (IASP) was founded in 1973, and its classification of chronic pain was adopted by the WHO ICD-11 in 2019.

Key Research Papers

  1. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971-979.
  2. Treede RD, et al. A classification of chronic pain for ICD-11. Pain. 2015;156(6):1003-1007.
  3. Gaskin DJ, Richard P. The economic costs of pain in the United States. Journal of Pain. 2012;13(8):715-724.
  4. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain. JAMA. 2016;315(15):1624-1645.
  5. Vos T, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries: Global Burden of Disease Study 2010. The Lancet. 2012;380(9859):2163-2196.
  6. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2-S15.
  7. Turk DC, Wilson HD, Cahana A. Treatment of chronic non-cancer pain. The Lancet. 2011;377(9784):2226-2235.
  8. Williams AC, Eccleston C, Morley S. Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database of Systematic Reviews. 2012;(11):CD007407.
  9. Apkarian AV, et al. Human brain mechanisms of pain perception and regulation in health and disease. European Journal of Pain. 2005;9(4):463-484.
  10. Chou R, Huffman LH. Nonpharmacologic therapies for acute and chronic low back pain: a review of the evidence. Annals of Internal Medicine. 2007;147(7):492-504.
  11. Bushnell MC, Ceko M, Low LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience. 2013;14(7):502-511.

Back to Table of Contents


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