Asthma

Table of Contents

  1. What is Asthma?
  2. Types of Asthma
  3. Common Symptoms of Asthma
  4. Risk Factors
  5. Prevention and Management Strategies
  6. Treatment Options
  7. Complications of Asthma
  8. Research Papers
  9. Connections
  10. Featured Videos

What is Asthma?

Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to difficulty breathing. It can range from mild to severe and often requires long-term management.

Types of Asthma

1. Allergic Asthma

2. Non-Allergic Asthma

3. Exercise-Induced Asthma

4. Occupational Asthma

Common Symptoms of Asthma

Risk Factors

Prevention and Management Strategies

Treatment Options

Complications of Asthma


References & Research

Historical Background

Asthma has been recognized since ancient times, with the term coined by Hippocrates around 450 BCE. Henry Hyde Salter provided one of the first modern clinical descriptions of asthma in his 1860 work On Asthma: Its Pathology and Treatment, establishing it as a distinct disease of airway spasm rather than a symptom of other conditions.

Key Research Papers

  1. Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(10122):783-800.
  2. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Eur Respir J. 2020;56(2):2000588.
  3. Pavord ID, Beasley R, Agusti A, et al. After asthma: redefining airways diseases. Lancet. 2018;391(10118):350-400.
  4. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716-725.
  5. Busse WW, Morgan WJ, Gergen PJ, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011;364(11):1005-1015.
  6. Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486-2496.
  7. Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198-1207.
  8. Pauwels RA, Pedersen S, Busse WW, et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial (START). Lancet. 2003;361(9363):1071-1076.
  9. Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma (TALC). N Engl J Med. 2010;363(18):1715-1726.
  10. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-178.
  11. Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med. 1999;340(3):197-206.
  12. Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med. 2006;144(12):904-912.

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Research Papers

The following PubMed topic searches surface the current peer-reviewed literature on Asthma. Each link opens a live PubMed query; results update as new papers are indexed.

  1. PubMed search: asthma pathophysiology
  2. PubMed search: asthma GINA guidelines
  3. PubMed search: asthma inhaled corticosteroid
  4. PubMed search: severe asthma biologic therapy
  5. PubMed search: asthma exacerbation management
  6. PubMed search: exercise induced bronchoconstriction
  7. PubMed search: occupational asthma
  8. PubMed search: allergic asthma IgE omalizumab
  9. PubMed search: eosinophilic asthma mepolizumab
  10. PubMed search: pediatric asthma
  11. PubMed search: asthma spirometry FEV1
  12. PubMed search: asthma phenotype endotype

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Connections

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