Cancer

What is Cancer?

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. If not controlled, it can result in serious health complications and death.

Types of Cancer

1. Carcinomas

2. Sarcomas

3. Leukemia

4. Lymphomas

5. Melanoma

Symptoms of Cancer

Symptoms vary depending on the type and location of the cancer, but common signs may include:

Risk Factors

Prevention Strategies

Treatment Options

Complications of Cancer


References & Research

Historical Background

Cancer has been documented since ancient Egypt, with the earliest known description found in the Edwin Smith Papyrus (c. 1600 BCE). The term "cancer" derives from the Greek physician Hippocrates (c. 460-370 BCE), who used the words "carcinos" and "carcinoma." Modern oncology advanced dramatically with Rudolf Virchow's cellular pathology theory in the 1850s and Sidney Farber's pioneering chemotherapy work in 1947.

Key Research Papers

  1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17-48.
  2. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide. CA Cancer J Clin. 2018;68(6):394-424.
  3. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
  4. Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12(1):31-46.
  5. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-2454.
  6. Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-723.
  7. Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500(7463):415-421.
  8. The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578(7793):82-93.
  9. Korde LA, Somerfield MR, Carey LA, et al. Neoadjuvant chemotherapy, endocrine therapy, and targeted therapy for breast cancer: ASCO guideline. J Clin Oncol. 2021;39(13):1485-1505.
  10. Vogelstein B, Papadopoulos N, Velculescu VE, et al. Cancer genome landscapes. Science. 2013;339(6127):1546-1558.
  11. Islami F, Goding Sauer A, Miller KD, et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors. CA Cancer J Clin. 2018;68(1):31-54.
  12. Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia (ELIANA). N Engl J Med. 2018;378(5):439-448.

Back to Table of Contents


Connections

Explore related topics across MyHealthcare: