Oncology

Table of Contents

1. Oncology
2. Research Papers
3. Connections
4. Featured Videos

Oncology is dedicated to the diagnosis, treatment, and prevention of cancer across all organ systems.

• Cancer — overview, staging systems, prevention, screening guidelines
• Leukemia — ALL, AML, CLL, CML, chemotherapy, targeted therapy
• Lymphoma — Hodgkin and non-Hodgkin, Ann Arbor staging, immunotherapy
• Metastatic Cancers — spread patterns, systemic therapy, palliative care
• Multiple Myeloma — plasma cell neoplasm, CRAB criteria, proteasome inhibitors
• Sarcoma — bone and soft tissue tumors, surgical management
• Thyroid Cancer — papillary, follicular, medullary, anaplastic, BRAF mutations, RAI therapy

Key Research Papers

Foundational and recent peer-reviewed publications across major oncology topics — immunotherapy, targeted therapy, screening, breast/prostate/lung/colon cancer, hematologic malignancies, and supportive care. Each citation links to the full text via DOI.

1. Hodi FS, O'Day SJ, McDermott DF, et al. Improved Survival with Ipilimumab in Patients with Metastatic Melanoma. New England Journal of Medicine. 2010;363(8):711-723.
2. Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer (KEYNOTE-024). New England Journal of Medicine. 2016;375(19):1823-1833.
3. Slamon DJ, Leyland-Jones B, Shak S, et al. Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2. New England Journal of Medicine. 2001;344(11):783-792.
4. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer. New England Journal of Medicine. 2012;366(26):2443-2454.
5. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia. New England Journal of Medicine. 2001;344(14):1031-1037.
6. National Lung Screening Trial Research Team. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. New England Journal of Medicine. 2011;365(5):395-409.
7. Ferlay J, Colombet M, Soerjomataram I, et al. Cancer Statistics for the Year 2020: An Overview. International Journal of Cancer. 2021;149(4):778-789.
8. Cardoso F, Kyriakides S, Ohno S, et al. Early Breast Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Annals of Oncology. 2019;30(8):1194-1220.
9. Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell. 2011;144(5):646-674.
10. June CH, Sadelain M. Chimeric Antigen Receptor Therapy. New England Journal of Medicine. 2018;379(1):64-73.
11. Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma (CheckMate 067). New England Journal of Medicine. 2015;373(1):23-34.
12. Bretthauer M, Løberg M, Wieszczy P, et al. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death (NORDICC Trial). New England Journal of Medicine. 2022;387(17):1547-1556.
13. André T, Shiu KK, Kim TW, et al. Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer (KEYNOTE-177). New England Journal of Medicine. 2020;383(23):2207-2218.
14. Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia (ELIANA). New England Journal of Medicine. 2018;378(5):439-448.
15. DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia (VIALE-A). New England Journal of Medicine. 2020;383(7):617-629.
16. Temel JS, Greer JA, Muzikansky A, et al. Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer. New England Journal of Medicine. 2010;363(8):733-742.

Live PubMed Searches

The following PubMed topic searches surface current peer-reviewed literature across oncology subfields. Each link opens a live query; results update as new papers are indexed.

1. Oncology review
2. Cancer epidemiology
3. Cancer staging
4. Chemotherapy
5. Immunotherapy & checkpoint inhibitors
6. Targeted therapy
7. Precision oncology & tumor genomics
8. Cancer screening guidelines
9. Cancer biomarkers
10. Radiation therapy
11. Cancer survivorship
12. Palliative care

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Connections

• All Conditions
• Cancer
• Leukemia
• Lymphoma
• Multiple Myeloma
• Sarcoma
• Thyroid Cancer
• Metastatic Cancers
• Selenium and Cancer Prevention — selenoprotein biology, the NPC and SELECT trials, evidence across prostate/colorectal/lung cancers, and the U-shaped dose-response curve.
• Turmeric
• Vitamin D3

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