Anxiety

Anxiety — scientific infographic poster
Anxiety amygdala fear circuit

🧠 Interactive Visualization The Stress Response — fire a stressor and watch cortisol rise Adrenaline spikes in a second, cortisol follows in minutes — then compare acute stress with chronic, and watch the feedback loop blunt. Launch → 🌤️ Interactive Visualization Serotonin, Mood & SSRIs — build it, fire it, block reuptake Assemble serotonin from tryptophan, fire it across the synapse, then take an SSRI and watch the cleft flood — or starve the tryptophan and watch the signal fade. Launch → 🛑 Interactive Visualization GABA, the Brain's Brake — press it with a benzo or alcohol Watch glutamate try to fire a neuron while GABA slams the chloride brake on — then add a benzodiazepine or alcohol and see the brake amplified, and why stacking them is dangerous. Launch → 🔗 Interactive Visualization The Gut-Brain Axis — hear the gut talk to the brain Follow the vagus nerve carrying signals up from your gut, the gut making most of your serotonin, and the microbiome shaping mood — then flip it and watch stress disrupt the gut. Launch →

Table of Contents

  1. What is Anxiety?
  2. Types of Anxiety Disorders
  3. Common Symptoms of Anxiety
  4. Causes and Risk Factors
  5. Diagnosis
  6. Treatment Options
  7. Prevention Strategies
  8. Complications of Anxiety
  9. Research Papers
  10. Connections
  11. Featured Videos

What is Anxiety?

Anxiety is a natural response to stress and involves feelings of fear or apprehension about future events. While occasional anxiety is a normal part of life, anxiety disorders are chronic and can interfere with daily activities.

Types of Anxiety Disorders

1. Generalized Anxiety Disorder (GAD)

2. Panic Disorder

3. Social Anxiety Disorder

4. Specific Phobias

5. Obsessive-Compulsive Disorder (OCD)

6. Post-Traumatic Stress Disorder (PTSD)

Common Symptoms of Anxiety

Causes and Risk Factors

Diagnosis

Treatment Options

Prevention Strategies

Complications of Anxiety


Research Papers

Historical Background

Anxiety as a clinical concept was first systematically described by Sigmund Freud in the 1890s, who distinguished "anxiety neurosis" from other nervous conditions. The modern classification of anxiety disorders began with the DSM-III in 1980, which separated anxiety into distinct categories including panic disorder, generalized anxiety disorder, and phobias.

Key Research Papers

  1. Kessler RC, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry. 2005;62(6):593-602.
  2. Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience. 2015;17(3):327-335.
  3. Craske MG, et al. Anxiety disorders. Nature Reviews Disease Primers. 2017;3:17024.
  4. Stein MB, Sareen J. Generalized anxiety disorder. New England Journal of Medicine. 2015;373(21):2059-2068.
  5. Barlow DH. Cognitive-behavioral therapy for panic disorder: current status. Journal of Clinical Psychiatry. 1997;58(Suppl 2):32-36.
  6. Bandelow B, et al. Efficacy of treatments for anxiety disorders: a meta-analysis. International Clinical Psychopharmacology. 2015;30(4):183-192.
  7. Hofmann SG, Smits JA. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. Journal of Clinical Psychiatry. 2008;69(4):621-632.
  8. Hettema JM, Neale MC, Kendler KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry. 2001;158(10):1568-1578.
  9. Craske MG, Stein MB. Anxiety. The Lancet. 2016;388(10063):3048-3059.
  10. Spitzer RL, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine. 2006;166(10):1092-1097.
  11. Shin LM, Liberzon I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology. 2010;35(1):169-191.
  12. Baxter AJ, et al. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychological Medicine. 2013;43(5):897-910.

PubMed Topic Searches

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Connections

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