Autism

Table of Contents

  1. What is Autism?
  2. Characteristics of Autism
  3. Signs and Symptoms of Autism
  4. Causes and Risk Factors
  5. Diagnosis
  6. Treatment Options
  7. Prevention and Early Intervention
  8. Challenges and Support for Individuals with Autism
  9. Complications Associated with Autism
  10. Research Papers
  11. Connections
  12. Featured Videos

What is Autism?

Autism, or Autism Spectrum Disorder (ASD), is a developmental disorder that affects communication, behavior, and social interaction. It is called a "spectrum" disorder because there is a wide range of symptoms and severity among individuals.

Characteristics of Autism

Signs and Symptoms of Autism

Signs and symptoms can vary widely among individuals, but common indicators include:

Causes and Risk Factors

Diagnosis

Treatment Options

Prevention and Early Intervention

Challenges and Support for Individuals with Autism

Complications Associated with Autism


Research Papers

Historical Background

Autism was first described independently by Leo Kanner in 1943 and Hans Asperger in 1944. Kanner identified "early infantile autism" in children who displayed social withdrawal and insistence on sameness, while Asperger described similar traits in higher-functioning children. The term "autism spectrum disorder" was adopted in the DSM-5 (2013), unifying previously separate diagnoses under one umbrella.

Key Research Papers

  1. Christensen DL, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years -- Autism and Developmental Disabilities Monitoring Network. MMWR Surveillance Summaries. 2016;65(3):1-23.
  2. Lai MC, Lombardo MV, Baron-Cohen S. Autism. The Lancet. 2014;383(9920):896-910.
  3. De Rubeis S, et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. 2014;515(7526):209-215.
  4. Geschwind DH, State MW. Gene hunting in autism spectrum disorder: on the path to precision medicine. The Lancet Neurology. 2015;14(11):1109-1120.
  5. Lord C, et al. Autism spectrum disorder. Nature Reviews Disease Primers. 2020;6(1):5.
  6. Hyman SL, et al. Identification, evaluation, and management of children with autism spectrum disorder (AAP Clinical Report). Pediatrics. 2020;145(1):e20193447.
  7. Dawson G, et al. Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics. 2010;125(1):e17-e23.
  8. Gaugler T, et al. Most genetic risk for autism resides with common variation. Nature Genetics. 2014;46(8):881-885.
  9. Courchesne E, et al. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011;306(18):2001-2010.
  10. Sanders SJ, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012;485(7397):237-241.
  11. Weitlauf AS, et al. Therapies for children with autism spectrum disorder: behavioral interventions update. Comparative Effectiveness Reviews. 2014;137.
  12. Satterstrom FK, et al. Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. Cell. 2020;180(3):568-584.

PubMed Topic Searches

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Connections

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