⚠ Evidence warning: Clinical trials or other evidence do not support the claims that bone broth's magnesium is highly absorbable, that bone broth may reduce the severity and duration of cold and flu symptoms, and that bones from organically raised, pasture-fed or wild animals tend to have lower heavy metal burdens. This page keeps it as a report of what people, websites or other media say.

Bone Broth: An Ancient Healing Superfood

Bone Broth — scientific infographic poster
Bone broth collagen, glycine, and glutamine breakdown

Table of Contents

Key Benefits at a Glance

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Overview

Bone broth is one of the most ancient and revered healing foods in the history of traditional medicine. For thousands of years, cultures across every continent have simmered animal bones for extended periods to produce a nutrient-dense, deeply nourishing liquid that supports virtually every system of the body. From the traditional Chinese practice of preparing bone soups for postpartum recovery to the European custom of slow-simmered stocks as the foundation of restorative cuisine, bone broth has earned its place as a cornerstone of ancestral nutrition.

Naturopathic practitioners describe bone broth as one of the most therapeutic and accessible foods available. In their account it provides a concentrated source of collagen, gelatin, and amino acids, along with minerals, in a form that the body can readily absorb and utilize, and unlike isolated supplements it delivers these nutrients in a whole-food matrix, allowing synergistic interactions that enhance absorption and therapeutic benefit. (The measured mineral amounts per serving are small; see the Mineral Content section.)

Practitioners see the modern resurgence of interest in bone broth as justified by traditional wisdom and emerging research, and describe it as a food that addresses multiple root causes of chronic disease at once, including intestinal permeability, chronic inflammation, nutrient deficiency, and immune dysregulation. Whether consumed as a warming beverage, a cooking base, or a therapeutic protocol, bone broth holds a prominent place in the healing diets they describe.

Collagen and Gelatin Content

The primary therapeutic value of bone broth lies in its extraordinary concentration of collagen and gelatin. Collagen is the most abundant protein in the human body, comprising approximately 30 percent of total protein mass. It forms the structural scaffolding of skin, bones, tendons, ligaments, cartilage, blood vessels, and the intestinal lining. When bones, connective tissues, and cartilage are simmered in water for extended periods, the collagen they contain is gradually extracted and partially hydrolyzed into gelatin.

Gelatin is the cooked form of collagen. A well-made bone broth will gel when refrigerated, which is a direct indicator of its gelatin content. This gel-forming property is not merely cosmetic; it reflects the presence of specific amino acid chains that provide the building blocks for the body to synthesize its own collagen. The gelatin in bone broth contains high concentrations of the amino acids glycine, proline, and hydroxyproline, which are essential for collagen production throughout the body.

Collagen production naturally declines with age, beginning as early as the mid-twenties and accelerating after age forty. This decline is associated with joint deterioration, thinning skin, weakened bones, and compromised gut integrity. Providing the body with dietary collagen and gelatin through bone broth supports the regeneration of these tissues and helps counteract the degenerative effects of aging.

The collagen in bone broth is primarily Type I and Type III collagen from beef and pork bones, and Type II collagen from chicken bones and cartilage. Type I collagen supports skin, bone, and tendon health, while Type II collagen is particularly beneficial for joint cartilage. A varied bone broth practice that includes different animal sources provides a broad spectrum of collagen types.

Gut Healing and Leaky Gut Repair

One of the most clinically significant applications of bone broth in naturopathic medicine is the repair of intestinal permeability, commonly known as leaky gut syndrome. The intestinal lining is a single-cell-thick barrier that must selectively allow nutrients to pass into the bloodstream while blocking toxins, undigested food particles, and pathogenic organisms. When this barrier is compromised, larger molecules pass through the tight junctions between cells, triggering systemic immune activation and chronic inflammation.

The gelatin in bone broth has a unique ability to support the integrity of the intestinal mucosal lining. Gelatin attracts and holds water, creating a protective coating along the intestinal wall that supports the mucus layer. This is particularly important for individuals with inflammatory bowel conditions, irritable bowel syndrome, food sensitivities, and autoimmune conditions that originate in the gut.

The amino acid glutamine, abundantly present in bone broth, is the primary fuel source for enterocytes, the cells that line the small intestine. Glutamine is considered a conditionally essential amino acid because the body's demand for it increases dramatically during times of stress, illness, or intestinal damage. Supplementing glutamine through bone broth provides the raw material these cells need to proliferate and repair the intestinal barrier.

Glycine, another amino acid concentrated in bone broth, stimulates the production of stomach acid and bile, improving the digestion and absorption of nutrients. Many patients with leaky gut also suffer from hypochlorhydria, or low stomach acid, which perpetuates the cycle of maldigestion and intestinal inflammation. The glycine in bone broth addresses this upstream cause.

In clinical practice, naturopathic practitioners use bone broth as a foundational component of gut-healing protocols, including elimination diets, the GAPS diet, and autoimmune paleo approaches, and many of their patients report significant improvement in digestive symptoms, food tolerance, and systemic inflammation within weeks of drinking bone broth daily.

Joint Health and Mobility

Bone broth is a traditional food for joint health, and practitioners count it among the most effective natural interventions for supporting joints and easing joint pain. The connective tissues, cartilage, and tendons that are simmered along with the bones release a rich supply of compounds that directly nourish the musculoskeletal system.

Glucosamine and chondroitin sulfate, two compounds widely sold as joint-support supplements, are naturally present in bone broth. These glycosaminoglycans are extracted from the cartilage and connective tissues during the long simmering process. Glucosamine stimulates the production of new cartilage and helps maintain the cushioning between joints, while chondroitin sulfate provides resistance to compression and supports the structural integrity of cartilage.

Hyaluronic acid, another glycosaminoglycan found in bone broth, is a major component of synovial fluid, the lubricating liquid within joint capsules. Adequate hyaluronic acid levels help reduce friction between joint surfaces, decrease pain with movement, and support overall joint mobility.

The Type II collagen extracted primarily from chicken bones and cartilage has been studied for its ability to modulate the immune response in joints affected by rheumatoid arthritis and other autoimmune joint conditions. Research suggests that oral consumption of Type II collagen can induce immune tolerance, reducing the autoimmune attack on joint tissues.

For osteoarthritis, rheumatoid arthritis, sports injuries, or age-related joint degeneration, practitioners describe daily bone broth as a therapeutic food, and report that the combination of collagen, glucosamine, chondroitin, and hyaluronic acid in a whole-food form often produces results comparable to or exceeding those achieved with isolated supplements.

Skin, Hair, and Nail Support

The collagen and gelatin in bone broth provide direct support for the health and appearance of skin, hair, and nails. These tissues are among the most collagen-dependent structures in the body, and their condition often reflects the body's overall collagen status.

Skin elasticity and hydration are largely determined by the density of the collagen network in the dermis, the deeper layer of the skin. As collagen production declines with age, the skin loses firmness and moisture, leading to wrinkles, sagging, and dryness. The amino acids glycine, proline, and hydroxyproline provided by bone broth serve as direct precursors for dermal collagen synthesis, supporting skin structure from within.

Hair follicles are surrounded by a collagen-rich sheath that provides structural support and nourishment. Thinning hair, slow hair growth, and brittle hair texture can all be associated with insufficient collagen and protein intake. The complete amino acid profile in bone broth, including the sulfur-containing amino acids, supports the production of keratin, the primary structural protein of hair.

Nails are composed largely of keratin and depend on adequate protein, mineral, and collagen intake for their strength and growth rate. Many patients report noticeable improvements in nail strength and reduced breakage within four to six weeks of regular bone broth consumption. The silica and trace minerals extracted from bones during the simmering process further contribute to nail integrity.

Unlike topical collagen products, which cannot penetrate the skin in meaningful amounts, the dietary collagen peptides and amino acids in bone broth are absorbed through the digestive system and distributed to the skin, hair, and nails through the bloodstream, providing genuine structural support from the inside out.

Amino Acid Profile: Glycine, Proline, and Glutamine

Bone broth contains a distinctive amino acid profile that sets it apart from other protein sources. While muscle meats are rich in methionine and other amino acids, bone broth is uniquely concentrated in glycine, proline, and glutamine, three amino acids that are critically important for healing and that are often deficient in modern diets.

Glycine is the most abundant amino acid in bone broth and serves an extraordinary range of functions in the body. It is essential for the synthesis of collagen, glutathione (the body's master antioxidant), creatine, heme, nucleic acids, and bile salts. Glycine acts as an inhibitory neurotransmitter, promoting calm and supporting restful sleep. It modulates inflammation by inhibiting the activation of immune cells and reducing the production of pro-inflammatory cytokines. Glycine also supports detoxification by conjugating with toxins in the liver, facilitating their excretion. Research suggests that most people consume far less glycine than is optimal for these functions, making bone broth a particularly valuable dietary addition.

Proline is a key amino acid for collagen synthesis and wound healing. It is converted in the body to hydroxyproline, which stabilizes the triple-helix structure of collagen. Proline also plays a role in maintaining the integrity of blood vessel walls and supporting cardiovascular health. The body can synthesize some proline, but production is often insufficient during periods of rapid growth, healing, or aging, making dietary sources essential.

Glutamine is the most abundant amino acid in the bloodstream and is critically important for intestinal health, immune function, and nitrogen transport. As described in the gut healing section, it is the primary fuel for enterocytes. Glutamine also serves as fuel for lymphocytes and other immune cells, supports acid-base balance in the kidneys, and acts as a precursor for the neurotransmitter glutamate. During periods of physical stress, surgery, infection, or intense exercise, the body's demand for glutamine can exceed its ability to produce it, making it a conditionally essential amino acid that must be obtained from diet.

The amino acid profile of bone broth helps balance the dietary excess of methionine that results from heavy consumption of muscle meats. Glycine works in concert with methionine in methylation pathways, and some researchers have suggested that the ratio of glycine to methionine in the diet may be more important for longevity than the absolute amount of either amino acid alone. Traditional diets that used the whole animal, including bones and connective tissues, naturally provided this balance.

Mineral Content: Calcium, Magnesium, and Phosphorus

Bones are the body's primary mineral reservoir, containing approximately 99 percent of the body's calcium, 85 percent of its phosphorus, and significant amounts of magnesium, along with trace minerals including zinc, manganese, iron, selenium, and boron. When bones are simmered for extended periods in slightly acidic water, some of these minerals are released into the broth. The amounts measured are small: a 2017 analysis of home-made and commercial bone broths (Hsu and colleagues) found calcium and magnesium at no more than low tenths of a milligram per serving, under 5% of daily recommended levels, and judged their contribution to daily needs to be small.

Calcium is essential for bone density, muscle contraction, nerve signaling, blood clotting, and cellular communication. Many individuals are deficient in calcium despite consuming dairy products, because absorption depends on cofactors including vitamin D, magnesium, and vitamin K2. Practitioners describe the calcium in bone broth as better used than isolated calcium supplements because it comes alongside these synergistic minerals, although the amount per serving is small.

Magnesium participates in over 300 enzymatic reactions in the body, including energy production, protein synthesis, muscle and nerve function, blood sugar regulation, and blood pressure control. Magnesium deficiency is widespread in modern populations due to depleted soils, processed food consumption, and chronic stress. Bone broth provides magnesium in a food-based, highly absorbable form. Bone broth contains some magnesium in a food-based form, but the 2017 measurements put it, like calcium, at under 5% of daily needs per serving.

Phosphorus is the second most abundant mineral in the body after calcium and is essential for bone and tooth structure, energy metabolism via adenosine triphosphate (ATP) production, DNA and RNA synthesis, and cell membrane integrity. The calcium-to-phosphorus ratio in bone broth closely mirrors the ratio found in healthy bone tissue, supporting balanced mineral metabolism.

The addition of an acidic medium, such as apple cider vinegar, to the simmering water significantly increases the extraction of minerals from the bones. In the 2017 study, lowering the broth's pH from 8.38 to 5.32 increased calcium extraction 17.4-fold and magnesium extraction 15.3-fold, and cooking for more than 8 hours drew out significantly more of both than shorter cooking times. The trace minerals in bone broth, including zinc, selenium, and manganese, provide additional support for immune function, antioxidant defense, and enzymatic processes throughout the body.

Immune System Support

Chicken soup has a long reputation as a home remedy for colds and respiratory infections, and bone broth, chicken bone broth in particular, is traditionally used the same way.

A 2000 laboratory study published in the journal Chest (Rennard and colleagues) tested a traditional chicken soup made with vegetables in a lab dish and found that it slowed the migration of neutrophils, a type of white blood cell involved in the inflammation of upper respiratory infections; the vegetables and the chicken each had this effect on their own. The authors suggested that a mild anti-inflammatory effect could be one way the soup eases cold symptoms. The study did not test bone broth itself or people who were ill; easing cold and flu symptoms remains the traditional use. By modulating the neutrophil response, bone broth may help reduce the severity and duration of cold and flu symptoms without suppressing the immune system's ability to fight the infection.

The amino acid cysteine, released from chicken bones and connective tissue during simmering, is a precursor to glutathione, the body's most powerful intracellular antioxidant. Glutathione is essential for the function of natural killer cells, T-cells, and other immune effectors. Supporting glutathione production through dietary cysteine intake helps maintain robust immune surveillance and response.

The gut-healing properties of bone broth also contribute indirectly but powerfully to immune function, given that approximately 70 to 80 percent of the immune system resides in the gut-associated lymphoid tissue. By repairing intestinal permeability and reducing the translocation of bacterial endotoxins into the bloodstream, bone broth helps resolve the chronic, low-grade immune activation that underlies many modern diseases.

Glycine's anti-inflammatory properties further support immune balance by preventing excessive inflammatory responses that can damage healthy tissue. This immunomodulatory effect is particularly valuable in autoimmune conditions, where the goal is not to suppress the immune system but to restore appropriate immune regulation.

For recurrent infections, chronic fatigue, autoimmune conditions, or recovery after surgery, practitioners describe bone broth as a daily therapeutic food that supports immune resilience from multiple angles at once.

Bone Health and Density

It is fitting that a food made from bones is traditionally used for maintaining and rebuilding bone tissue. Practitioners describe bone broth as supplying the raw materials of bone: collagen, plus calcium, magnesium, phosphorus, and trace minerals, although the 2017 measurements put its calcium and magnesium at under 5% of daily needs per serving.

Bone is not merely a mineral deposit; it is a living tissue composed of a collagen matrix that is mineralized with hydroxyapatite crystals. The collagen framework provides flexibility and tensile strength, while the minerals provide rigidity and compressive strength. Both components are essential, and deficiency in either leads to compromised bone integrity. Most conventional approaches to bone health focus exclusively on calcium and vitamin D supplementation while neglecting the collagen component, which may explain their limited effectiveness in many patients.

The collagen peptides in bone broth have been shown to stimulate osteoblast activity, the bone-building cells responsible for laying down new bone matrix. Simultaneously, glycine and proline support the cross-linking of collagen fibers that gives bone its characteristic strength and resilience. This dual action, stimulating both the organic and mineral phases of bone, makes bone broth a comprehensive intervention for osteopenia and osteoporosis prevention.

Practitioners credit the balanced ratio of calcium, magnesium, and phosphorus in bone broth with supporting the mineralization of new bone tissue, and contrast it with isolated calcium supplements, which they say can accumulate in soft tissues when taken without adequate cofactors; the measured amounts of these minerals per serving are small.

For postmenopausal women, elderly individuals, athletes with high bone turnover demands, and anyone with a family history of osteoporosis, practitioners describe daily bone broth as one of the most accessible and effective strategies for long-term bone health.

Preparation Methods: Beef vs Chicken vs Fish

Different types of bones produce broths with distinct nutritional profiles and therapeutic applications. A well-rounded bone broth practice ideally incorporates multiple animal sources to obtain the broadest spectrum of nutrients.

Beef bone broth is the richest source of Type I and Type III collagen, which support skin, bone, and tendon health. Beef bones, particularly marrow bones and knuckle bones, are dense and mineral-rich, producing a deeply flavored, thick broth with high gelatin content. Beef marrow bones also contribute fat-soluble nutrients and immune-supporting compounds from the marrow itself. Oxtails and short ribs provide an excellent combination of bone, cartilage, and connective tissue. Beef bone broth typically requires the longest simmering time, between 24 and 48 hours, to fully extract nutrients from the dense bone structure.

Chicken bone broth is the most widely consumed and is particularly valued for its Type II collagen content, which supports cartilage and joint health. Chicken feet, necks, and backs are exceptionally rich in collagen and gelatin, and their inclusion dramatically improves the gel quality of the finished broth. Chicken bone broth tends to be lighter in flavor and easier to digest, making it ideal for individuals with sensitive digestive systems or those new to bone broth consumption. It is the classic choice for immune support during illness. Chicken broth typically simmers for 12 to 24 hours.

Fish bone broth is the fastest to prepare, requiring only 6 to 8 hours of simmering, because fish bones are thinner and more porous than mammalian bones. Fish broth is an excellent source of iodine and other trace minerals, as well as collagen from the skin, fins, and head. The collagen in fish broth has a lower molecular weight than mammalian collagen, which may enhance its absorption. Fish heads, in particular, are prized in traditional cuisines for their rich content of thyroid-supporting nutrients and healthy fats. Non-oily fish such as snapper, halibut, sole, and turbot produce the best-flavored broths.

Practitioners describe rotating between beef, chicken, and fish bone broths through the week, for exposure to all collagen types, a diverse mineral profile, and varied amino acid ratios.

Cooking Guidelines: The 24-48 Hour Slow Simmer

The quality and therapeutic potency of bone broth depend heavily on preparation technique. A properly made bone broth requires patience, quality ingredients, and attention to a few critical details.

Simmering times by bone type on one hours scale: fish bones 6 to 8 hours, chicken bones 12 to 24 hours, beef or lamb bones 24 to 48 hours, with the shorter under-8-hour chicken and under-12-hour beef options for histamine-sensitive readers, and an arrow showing that a longer simmer extracts more collagen, gelatin and minerals but also builds more histamine and free glutamate. HOW LONG TO SIMMER denser bones need longer · one scale of hours Fish bones · 6 to 8 hours Chicken bones · 12 to 24 hours histamine-sensitive: under 8 hours Beef or lamb bones · 24 to 48 hours histamine-sensitive: under 12 hours 6812 2448 hours at a bare simmer → longer simmer: more collagen, gelatin and minerals drawn out … and more histamine and free glutamate WHY THE TIMES DIFFER thin bones give up fast fish bones are thinner and more porous than beef bones 48 hours beats 12 a full beef simmer is noticeably thicker and more gelatinous the cost is histamine sensitive readers trade some extraction for a shorter pot a broth that gels in the fridge is showing you its gelatin.

Selecting bones: Choose bones from pasture-raised, grass-fed, or wild-caught animals whenever possible. The nutritional quality of the broth directly reflects the quality of the animals from which the bones were sourced. A good combination for beef broth includes marrow bones, knuckle bones, oxtails, and short ribs. For chicken broth, use a whole carcass along with extra feet, necks, and backs. Ask your local butcher or farmer for bones; they are often inexpensive or even free.

Roasting (optional): For beef bone broth, roasting the bones at 400 degrees Fahrenheit for 30 to 45 minutes before simmering deepens the flavor and color of the finished broth. This step is optional but recommended for the richest-tasting result. Chicken bones do not require roasting.

The simmer: Place bones in a large stockpot or slow cooker. Cover with cold, filtered water by about two inches. Add two tablespoons of apple cider vinegar and allow the mixture to sit for 30 minutes before applying heat. This resting period allows the acid to begin drawing minerals from the bones. Bring the water to a gentle boil, then reduce heat to maintain a bare simmer. The surface should show only occasional small bubbles. A vigorous boil will emulsify fats and produce a cloudy, less palatable broth.

Simmering times:

Longer simmering times result in more thorough extraction of collagen, gelatin, minerals, and glycosaminoglycans. A well-made beef bone broth simmered for a full 48 hours will be noticeably thicker and more gelatinous than one simmered for only 12 hours.

Skimming: During the first hour of simmering, foam and impurities will rise to the surface. Skim these off periodically with a ladle or fine-mesh strainer. After the first hour, skimming is rarely necessary.

Aromatics (optional): Vegetables such as onions, carrots, celery, garlic, and herbs including parsley, thyme, and bay leaves may be added during the last two to four hours of simmering for flavor. Adding vegetables too early can produce bitter or overcooked flavors.

Straining and storing: Strain the finished broth through a fine-mesh strainer and discard the solids. Allow the broth to cool, then refrigerate. A layer of fat will solidify on top, which acts as a natural seal and preservative. Bone broth keeps in the refrigerator for five to seven days and can be frozen for up to six months.

Key Ingredients and the Role of Apple Cider Vinegar

While bone broth can be made with nothing more than bones and water, a few key ingredients significantly enhance its nutritional value and therapeutic potency.

Apple cider vinegar is the single most important addition to any bone broth. The acetic acid in vinegar lowers the pH of the water, creating a mildly acidic environment that facilitates the dissolution of hydroxyapatite crystals and the release of calcium, magnesium, phosphorus, and other minerals from the bone matrix. Without this acidic medium, mineral extraction is substantially reduced. Use approximately two tablespoons of raw, unfiltered apple cider vinegar per gallon of water. Lemon juice or white wine vinegar may be substituted, though apple cider vinegar is preferred for its own health-promoting properties, including beneficial enzymes and organic acids.

Quality bones from well-raised animals are the foundation of therapeutic bone broth. Bones from pasture-raised, grass-fed cattle contain higher levels of omega-3 fatty acids, conjugated linoleic acid, and fat-soluble vitamins than those from conventionally raised animals. Similarly, pasture-raised chicken bones and wild-caught fish bones provide superior nutritional profiles. Include a variety of bone types: marrow bones for mineral-rich marrow, knuckle and joint bones for cartilage and glycosaminoglycans, and meaty bones for flavor and additional amino acids.

Filtered water is commonly used to keep chlorine, fluoride, and other water treatment chemicals out of the broth; practitioners say these may interfere with mineral absorption or add to toxin burden. Use enough water to cover the bones by approximately two inches.

Sea salt may be added to taste after the broth is finished. Unrefined sea salt provides additional trace minerals including iodine, zinc, and selenium. Adding salt during cooking is also acceptable but makes it harder to control the final seasoning, especially if the broth is reduced.

Fresh herbs and aromatics such as parsley, garlic, ginger, turmeric, and black pepper can be added in the final hours of cooking to enhance both flavor and therapeutic value. Parsley is often included for its vitamin C content, which supports collagen synthesis, and its mineral-chelating properties.

Daily Amounts Practitioners Describe

No official intake level exists for bone broth; the amounts practitioners describe vary with health goals, current health status, and the condition being addressed. The figures below are the ones commonly given in naturopathic practice.

General health maintenance: One to two cups (8 to 16 ounces) of bone broth per day provides a solid foundation of collagen, gelatin, amino acids, and minerals to support overall health and prevent degenerative changes in joints, bones, skin, and gut.

Gut healing protocols: Two to three cups per day, ideally consumed between meals or as a meal replacement during the initial phase of a gut-healing protocol. Some practitioners describe a bone broth fast of three to five days, consuming four to six cups daily, as an intensive reset for severely compromised gut health. A PubMed search finds no published study of a bone broth fast, so what is known about it comes from practitioners' descriptions.

Joint pain and arthritis: Two to three cups per day, with an emphasis on chicken bone broth made with feet and cartilage-rich parts for its Type II collagen content.

Post-surgical or post-illness recovery: Two to four cups per day to provide the concentrated amino acids, minerals, and immune-supporting compounds needed for rapid tissue repair and immune reconstitution.

Skin, hair, and nail support: One to two cups per day, consumed consistently for at least six to eight weeks before evaluating results, as collagen turnover in these tissues is gradual.

Bone broth can be consumed on its own as a warm beverage, used as the liquid base for soups and stews, added to grains and legumes during cooking, or incorporated into sauces and gravies. For maximum therapeutic benefit, sipping plain bone broth between meals allows the amino acids and gelatin to contact the intestinal lining directly without competition from other foods for absorption.

Signs Practitioners Link to Needing More Bone Broth

Practitioners describe the following signs and symptoms as signals that the body may be short of the nutrients bone broth provides, and as reasons they increase bone broth intake.

When several of these symptoms occur together, practitioners describe a daily bone broth routine of at least 30 days as a way to judge its effect.

Cautions and Considerations

While bone broth is generally safe and well-tolerated, there are several considerations to keep in mind.

Histamine sensitivity: Bone broth is a high-histamine food due to the prolonged cooking process. Individuals with histamine intolerance, mast cell activation syndrome, or certain allergic conditions may experience headaches, flushing, hives, digestive upset, or other histamine-related symptoms. For these individuals, shorter cooking times (under 8 hours for chicken, under 12 hours for beef) may reduce histamine content. Pressure-cooking bones for two to three hours is another option that produces a lower-histamine broth while still extracting meaningful nutrients.

Lead and heavy metal content: Bones can accumulate heavy metals, including lead, from the animal's environment and diet. Two studies that measured lead in bone broth reached different verdicts. A small 2013 blinded study (Monro and colleagues) tested broths made from organic chickens and found several times more lead than in the water used to make them: 9.5 micrograms per litre in broth made from the skin and cartilage and 7.01 micrograms per litre in chicken-bone broth, against 0.89 micrograms per litre in tap water treated the same way; the authors called these markedly high. A 2017 study (Hsu and colleagues) found lead and cadmium in bone broths at a few micrograms per serving and judged the risk minimal. Bones from organically raised, pasture-fed, or wild animals tend to have lower heavy metal burdens than conventionally raised livestock. Because the 2013 broths were made from organic chickens, buying organic did not keep lead out of them. The concern is greatest for bones from animals raised in areas with known environmental contamination.

Glutamate sensitivity: The long cooking process can produce free glutamate, a naturally occurring amino acid that some sensitive individuals may react to with symptoms similar to monosodium glutamate (MSG) sensitivity, including headaches, flushing, and palpitations. Reducing cooking time or diluting the broth may help those with glutamate sensitivity.

Oxalate considerations: For people following a low-oxalate diet for kidney stone prevention, some vegetables commonly added to bone broth, such as celery and parsley, contain oxalates; broth made without these additions does not carry them.

Medication interactions: The glycine content of bone broth may interact with certain medications, including clozapine and some sedative medications. The clozapine evidence comes from high-dose glycine: in a small 1999 double-blind trial (Potkin and colleagues, 19 patients with treatment-resistant schizophrenia), adding 30 grams of glycine a day to clozapine for 12 weeks gave no improvement, while patients on clozapine alone had a 35% reduction in positive symptoms, and the authors concluded that glycine may interfere with clozapine's antipsychotic effect. That dose is far above what bone broth supplies.

Digestive adjustment: Some individuals may initially experience digestive changes when beginning regular bone broth consumption, including mild bloating or changes in stool consistency. These effects typically resolve within a few days as the digestive system adjusts. Starting with a small amount, such as half a cup per day, and gradually increasing intake can minimize this adjustment period.

Bone broth is a food, not a substitute for medical care. Practitioners who regard it as a powerful therapeutic food use it as one part of a wider health plan that takes account of individual needs, underlying conditions, and overall diet.

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Key Research Papers

Selected peer-reviewed literature relevant to the therapeutic claims discussed above. Links resolve to PubMed or DOI.

  1. Rennard BO, Ertl RF, Gossman GL, Robbins RA, Rennard SI. Chicken soup inhibits neutrophil chemotaxis in vitro. Chest. 2000;118(4):1150-7. — PubMed PMID: 11035691
  2. Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008;24(5):1485-1496. — PubMed PMID: 18416885
  3. Proksch E, Segger D, Degwert J, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology. Skin Pharmacol Physiol. 2014;27(1):47-55. — PubMed PMID: 23949208
  4. Search PubMed
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  7. Wald A, Adibi SA. Stimulation of gastric acid secreted by glycine and related oligopeptides in humans. Am J Physiol. 1982;242(2):G85-8. — PubMed PMID: 7065145
  8. Search PubMed
  9. Monro JA, Leon R, Puri BK. The risk of lead contamination in bone broth diets. Med Hypotheses. 2013;80(4):389-90. — PubMed PMID: 23375414
  10. Hsu DJ, Lee CW, Tsai WC, Chien YC. Essential and toxic metals in animal bone broths. Food Nutr Res. 2017;61(1):1347478. — PubMed PMID: 28804437
  11. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry. 1999;156(1):145-7. — PubMed PMID: 9892314
  12. PubMed — bone broth / collagen / gut health review search. — Search PubMed
  13. PubMed — glycine / proline / collagen synthesis search

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Connections

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