Perilla and Memory: Leaf Extract and Seed Oil Trials

Table of Contents

1. Two Products, Two Lines of Research
2. The Leaf Extract Trial in Cognitive Impairment
3. The Seed Oil Trials in Healthy Adults
4. The Two Combination Trials
5. The Dementia Trial With a Null Result
6. All Human Trials at a Glance
7. What the Oil Contains and What the Body Makes of It
8. Rosmarinic Acid and Luteolin in Animal and Cell Studies
9. Traditional Use in Korea, Japan, China and Vietnam
10. Safety Findings
11. Who Funded the Trials
12. What Is Not Known
13. Key Research Papers
14. Connections
15. Featured Videos

Two Products, Two Lines of Research

Purple perilla leaf extract. The one leaf trial used a 60 per cent ethanol extract of the leaves of Perilla frutescens var. acuta, the purple-leaf type. It was standardized to rosmarinic acid, a polyphenol found in many mint-family herbs. The research group behind it first tested the same extract in mice and cells, then ran a 12-week placebo-controlled trial in Korea.

Perilla seed oil. The oil trials come mainly from one university group in Shimane, Japan, which ran several 12-month studies in healthy adults and older people, plus one independent trial in Thailand in people already diagnosed with dementia. The oil's main ingredient is alpha-linolenic acid, so these trials are, in practice, tests of a plant omega-3 fat.

The two products do not stand in for each other. A finding on the leaf extract says nothing about the oil, and the reverse. Seed oil carries almost none of the leaf polyphenols, and the leaf extract carries almost none of the oil's fat.

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The Leaf Extract Trial in Cognitive Impairment

Design. Baek and colleagues (2026) ran a randomized, double-blind, placebo-controlled trial in Korea. One hundred adults with cognitive impairment were assigned 50 to the extract and 50 to placebo. The trial gave 500 mg of the extract a day for 12 weeks. The full text adds the entry rules: participants were 55 or older and scored 25 to 28 on the Korean Mini-Mental State Examination-2, a 30-point screening test where lower scores mean more impairment — a range that covers mild problems, not dementia. Of 113 people screened, 100 were enrolled and 93 finished (47 on extract, 46 on placebo). The extract was standardized to 12.7 mg of rosmarinic acid per gram, which works out to about 6.4 mg of rosmarinic acid a day at 500 mg of extract (this arithmetic is ours, not the paper's).

What improved. After 12 weeks the extract group improved more than the placebo group on the total score of the Korean Mini-Mental State Examination-2 and on two of its parts (attention and calculation, and language). It also improved more on the Alzheimer's Disease Assessment Scale–Cognitive Subscale, a longer memory and language test, and on six of its parts: word recall, following commands, delayed word recall, naming, word recognition and remembering instructions. Both groups improved; the extract group improved by more.

What did not change. The two blood markers did not differ between the groups: amyloid beta, the protein that builds up in Alzheimer's disease, and brain-derived neurotrophic factor, a protein involved in nerve-cell growth and survival. So the test scores moved, but the two measured biological signals did not.

Safety. The authors found no clinically significant changes in the safety tests, which in the full text included reported adverse events, blood tests, vital signs and an electrocardiogram.

Limits the authors state. The full text names a small number of completers and a short 12-week run, and calls for larger and longer trials. It is a single trial at a single size; it has not been repeated by another group.

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The Seed Oil Trials in Healthy Adults

Twelve months in adults aged 30 to 78 (2020)

Hashimoto and colleagues gave 75 healthy Japanese adults either perilla seed oil or a placebo for 12 months, measuring mood with the Zung Self-Rating Depression Scale and an apathy scale. The full text describes it as randomized and double-blind, with 7.0 mL of perilla oil a day against 7.0 mL of olive oil as the placebo, in identical packages; 65 people (86.3 per cent) finished. The abstract reports that depression and apathy scores improved significantly within the perilla group, that serum norepinephrine and serotonin fell compared with the control group, and that alpha-linolenic acid rose in red-blood-cell membranes.

The other side, from the full text: the authors write that the participants' mental health scores were mostly normal and that there were no significant differences between the perilla and placebo groups in the scores themselves. The between-group differences they report are in the change from baseline, at 3 and 12 months. The change in the depression score differed in women but not in men. And apart from alpha-linolenic acid, no red-blood-cell fatty acid changed — eicosapentaenoic acid and docosahexaenoic acid included. Memory was not measured in this study.

Twelve months in older adults aged 64 to 84 (2021)

The same group randomly divided 75 healthy older volunteers into a control group and a perilla oil group for 12 months. The abstract reports that serum antioxidant potential and red-blood-cell alpha-linolenic acid ended higher in the perilla group, and that a thinking test (the Frontal Assessment Battery) and apathy scores “tended to be improved” — wording that means the change did not reach statistical significance.

The full text adds the details that matter for reading it. The trial was single-blind: participants were not told which oil they had, but the authors note they may have told them apart by taste and smell. The control group took 7.0 mL of canola oil a day and the perilla group 7.0 mL of perilla oil, which the authors put at about 4 g of alpha-linolenic acid. Fifty-nine finished (24 control, 35 perilla). The authors' own limitations section says there were no significant differences between the perilla and control groups. Eicosapentaenoic acid and docosahexaenoic acid in red-blood-cell membranes did not change, and serum brain-derived neurotrophic factor was unaffected. At the start, blood sugar and a long-term blood sugar marker (glycated hemoglobin) were already lower in the perilla group than in the control group.

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The Two Combination Trials

Two later 12-month, randomized, double-blind trials from the Shimane group compared perilla oil alone with perilla oil plus a second plant powder. Both list the same trial registry number (UMIN000040863). In both, every participant got the oil; there was no placebo group taking neither.

Oil plus ponkan citrus powder (2022). Forty-nine healthy older Japanese adults took capsules with 1.47 mL of perilla oil (0.88 g of alpha-linolenic acid) a day, or the same oil plus 1.12 g of ponkan powder containing 2.91 mg of nobiletin, a citrus flavonoid. At the end, the combination group had significantly higher cognitive index scores than the oil-only group, along with higher red-blood-cell alpha-linolenic acid and docosahexaenoic acid, higher serum brain-derived neurotrophic factor and higher antioxidant potential.

Oil plus Anredera cordifolia leaf powder (2022). The same oil dose was compared with oil plus 1.12 g of Anredera cordifolia (Madeira vine) leaf powder a day. The combination group showed “generally higher” cognitive index scores than the oil-only group, with higher red-blood-cell alpha-linolenic acid and eicosapentaenoic acid and lower serum triglycerides, glucose and an advanced glycation end-product marker.

What these two trials can and cannot show. Because the oil was in both arms, any difference belongs to the added powder, not to perilla oil. The trials do not measure what the oil does on its own against nothing.

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The Dementia Trial With a Null Result

The largest perilla brain trial found is also the only one in people already diagnosed with dementia. Kamalashiran and colleagues in Thailand (2019) ran a double-blind, randomized trial of perilla seed oil against placebo, added to standard treatment for six months, in people with mild to moderate dementia. Cognitive function was compared nine months after enrollment. One hundred eighty-two people completed it, 94 on oil and 88 on placebo. The abstract does not give the daily amount of oil.

Result: cognitive function did not differ significantly between the groups. The authors conclude that perilla seed oil added to standard treatment does not improve cognitive function in mild to moderate dementia. Total cholesterol and low-density lipoprotein cholesterol were significantly lower in the oil group, and the oil showed no adverse effect on kidney, liver, blood counts or glucose metabolism.

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All Human Trials at a Glance

A related trial used a different plant oil with the same main fat: 60 healthy Japanese adults aged 65 to 80 took 3.7 g of flaxseed oil a day (2.2 g of alpha-linolenic acid) or a corn oil placebo for 12 weeks. Of six areas of thinking tested, only verbal fluency improved more than on placebo; the other scores did not differ. A 2022 review of alpha-linolenic acid describes its role in cognition as at an early stage of research.

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What the Oil Contains and What the Body Makes of It

Perilla seed oil is mostly alpha-linolenic acid. In the fatty-acid table of the 2020 trial (full text), the perilla oil used was about 50 g of alpha-linolenic acid per 100 mL, against about 14 g of linoleic acid and 27 g of oleic acid. Composition varies by crop; the perilla seed oil page covers it in detail.

Most of the research linking omega-3 fats to the brain concerns eicosapentaenoic acid and especially docosahexaenoic acid, the long-chain forms in fish and algae. Docosahexaenoic acid is a major structural fat in brain cell membranes. Alpha-linolenic acid is their eighteen-carbon starting material, and the body converts only part of it.

• In men. Burdge and colleagues gave six young men labelled alpha-linolenic acid with a meal and followed it for 21 days. The label showed up in eicosapentaenoic acid and docosapentaenoic acid, but there was no detectable enrichment of docosahexaenoic acid at any time point. About 33 per cent of the dose was burned for energy and breathed out within the first day. The authors conclude that in adult men the capacity to convert alpha-linolenic acid to docosahexaenoic acid is very low or absent.
• In women. The companion study gave 700 mg of labelled alpha-linolenic acid to young women and followed it for 21 days. Estimated net conversion was 21 per cent to eicosapentaenoic acid, 6 per cent to docosapentaenoic acid and 9 per cent to docosahexaenoic acid; about 22 per cent was breathed out within the first day. The authors suggest women of reproductive age have a greater capacity for conversion than men.

What the perilla trials measured in blood. In both 12-month trials of oil alone (2020 and 2021), red-blood-cell alpha-linolenic acid rose but docosahexaenoic acid did not change, according to the full texts. In the 2022 ponkan trial, docosahexaenoic acid rose in the combination group; in the Anredera trial, eicosapentaenoic acid rose in the combination group. In a 2026 Korean trial in healthy smokers, 4.8 g of perilla oil a day for 8 weeks raised alpha-linolenic acid in plasma and red blood cells and eicosapentaenoic acid in plasma.

Put together: perilla oil reliably raises the body's alpha-linolenic acid. Its effect on brain-relevant docosahexaenoic acid in these trials ranged from none to a rise only when another powder was added. Perilla oil is not a source of docosahexaenoic acid.

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Rosmarinic Acid and Luteolin in Animal and Cell Studies

Everything in this section is animal or cell work. None of it is a human result.

Rosmarinic acid

• In mice given amyloid beta injected into the brain, a Perilla frutescens var. japonica extract at 50 mg/kg a day, or rosmarinic acid at 0.25 mg/kg a day, for 14 days improved performance in maze and object-recognition tests and lowered markers of oxidative stress in the brain (Lee 2016).
• In mice in the forced-swim test, a water extract of perilla leaf (Perillae Herba) shortened immobility, a behaviour used to screen antidepressants; the fraction responsible was rich in rosmarinic acid, and a perilla extract low in rosmarinic acid had no effect (Takeda 2002).
• In mice, rosmarinic acid from perilla leaf given for 7 or 14 days increased the number of newly formed cells in the hippocampus, the brain's memory centre, alongside reduced immobility in the same swim test (Ito 2008).
• In mice and in cultured microglial cells, the standardized purple perilla leaf extract later used in the human trial reduced inflammatory signals in the cells and, in mice injected with amyloid beta, improved four memory tests (Kwon 2025). In mice given scopolamine, a drug that blocks a memory chemical, the same extract at 100, 250 and 500 mg/kg improved memory tasks, and in slices of mouse hippocampus it strengthened long-term potentiation, the cellular signal behind learning (Lee 2025).

The one human absorption study. In six healthy men given a single dose of perilla extract containing 200 mg of rosmarinic acid, rosmarinic acid and its methylated form appeared in the blood, peaking at 0.5 and 2 hours, and were mostly present in conjugated forms. Only 6.3 per cent of the dose was recovered in urine as rosmarinic acid and its breakdown products, about three-quarters of it within 6 hours (Baba 2005). Whether rosmarinic acid reaches the human brain was not measured.

Luteolin

• In cultured rat brain neurons, luteolin isolated from ripe perilla seed protected the cells against hydrogen peroxide, with efficacy higher than vitamin E; it did not have this effect in a human neuroblastoma cell line (Zhao 2012).
• In cells engineered to carry monoamine transporters, luteolin and apigenin from perilla fruit increased uptake of dopamine more than of norepinephrine and serotonin (Zhao 2010).
• In mice deprived of sleep, luteolin-7-O-glucuronide, a luteolin compound found in perilla, improved depression-like behaviour, lowered blood corticosterone and raised hippocampal brain-derived neurotrophic factor (Ryu 2022).

Seed oil in animals

In rats aged artificially with D-galactose for 8 weeks, perilla seed oil at 100 or 500 mg/kg improved spatial and recognition memory and raised one antioxidant enzyme in the hippocampus; it did not restore the lost nerve cells in the CA3 region (Jeefoo 2026).

The luteolin brain page covers luteolin from all food sources. The doses in these animal studies are by body weight and were not designed to match a food or supplement amount in people.

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Traditional Use in Korea, Japan, China and Vietnam

Perilla comes from East Asia, where the leaves, seeds and stems have long been used both as food and as traditional medicine (Ahmed 2018). The following are traditional uses, not tested results.

• China. Traditional Chinese medicine treats perilla leaf (zi su ye) and perilla seed (zi su zi) as separate medicinal materials. A 2018 review lists traditional uses that include depression-related illness, anxiety, headache and use as a sedative, alongside colds, cough and digestive complaints (Ahmed 2018).
• Japan. The leaf drug Perillae Herba appears in traditional East Asian herbal formulas, including Japanese Kampo formulas; an animal-study paper describes those formulas as used mainly for mood problems such as depression and anxiety (Takeda 2002). Perilla is one ingredient among several in those formulas, so no formula result can be credited to it. In Japanese cooking the leaf is shiso, and the seed oil is egoma oil.
• Korea. The large leaf (kkaennip) is an everyday food, and the seed is pressed into deulgireum oil or ground into stews. The purple-leaf type tested in the Korean leaf-extract trial is described by its authors as traditionally used in East Asian medicine for cough and asthma.
• Vietnam. The leaf, tía tô, is eaten raw with meals and used in folk remedies for colds and fever.

No traditional source treats perilla as a memory medicine in the way the modern trials frame it. The brain-related traditional uses are about mood, anxiety and calming.

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Safety Findings

In the trials. The 12-week leaf extract trial found no clinically significant changes in its safety tests. The Thai dementia trial reported no adverse effect of the oil on kidney, liver, blood counts or glucose metabolism. In the 2020 trial, the full text reports no side effects that disturbed daily life in either group; people with a known allergy to perilla oil were excluded at the start.

Perilla ketone. Some perilla plants, especially wild and weedy types, contain perilla ketone, a documented lung toxin in cattle and other livestock. Plant type cannot be told by sight. The trial products here are a seed oil and a leaf extract from cultivated material; the full story of chemotypes, the veterinary record and the open human question is on Perilla: Perilla Ketone, Species and Safety.

Seed allergy. Perilla seed is a recognized food allergen. Two cases of anaphylaxis caused by perilla seed were reported in 2006. A 2023 Korean study described 21 children with perilla seed allergy: median age 3, and 28.6 per cent had anaphylaxis. Skin prick tests were positive in all 15 children tested, and 85.7 per cent had perilla-specific allergy antibodies; oleosin, a seed protein, was identified as a major allergen. A 2024 Spanish report described allergy to white perilla with cross-reactivity to sesame. Anaphylaxis — throat swelling, difficulty breathing, a drop in blood pressure — is a sign hospitals treat as an emergency.

Interactions as reported. In the 2026 trial in healthy smokers, 4.8 g of perilla oil a day for 8 weeks significantly lengthened a platelet clotting test (the collagen–adenosine diphosphate closure time). That is a laboratory measure of slower platelet clumping, not a bleeding event. No trial found here tested perilla oil or leaf extract together with blood-thinning medicines or with dementia medicines. The safety page discusses the anticoagulant question at more length.

Oxidation. Perilla seed oil oxidizes easily because of its high alpha-linolenic acid content; how that happens is covered on the seed oil page.

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Who Funded the Trials

• Leaf extract trial (2026). Funded by the company that makes the extract; three of the seven authors are its employees. The paper states the funder had no role in design, analysis or writing. The two preceding mouse studies of the same extract were also funded by that company, with its employees as co-authors.
• Seed oil trials in healthy adults (2020, 2021). Funded by a Japanese government research grant; the authors declare no competing interests.
• Combination trials (2022). Two co-authors list affiliation with a private company; the abstracts do not state the funding source.
• Thai dementia trial (2019). The PubMed record lists non-U.S.-government research support; the abstract does not name the source.
• Flaxseed oil comparison trial (2023). Funded by a food company; two authors are its employees.
• Rosmarinic acid absorption study (2005). The first author is at a food company.

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What Is Not Known

• Whether the leaf extract result repeats. There is one 100-person, 12-week trial, funded by the maker. No independent group has tested it, and no trial has run longer than 12 weeks.
• Whether the leaf extract changes the course of a disease. Test scores improved, but the two blood markers did not, and no trial measured progression to dementia, brain imaging or daily function.
• Whether perilla oil alone helps memory. The placebo-controlled oil trial in dementia was negative; the healthy-adult trials found trends, within-group changes or comparisons between two oil products, not clear differences against an inactive control.
• The oil dose in the dementia trial, which its abstract does not report.
• Whether rosmarinic acid or luteolin from perilla reach the human brain at levels that act in animals and cells. Human absorption of rosmarinic acid is low and short-lived, and the brain was not measured.
• Whether the effect, if any, belongs to perilla. Rosmarinic acid is abundant in rosemary, lemon balm and other mint-family herbs, and alpha-linolenic acid is abundant in flaxseed, chia and walnuts.
• Long-term safety of the leaf extract beyond 12 weeks, and its use alongside prescription medicines.

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Key Research Papers

1. Baek HI, Joo JC, Kim SK, Park MH, Cho GH, Shen L, et al. Efficacy and Safety of Standardized Ethanol Extract of Purple Perilla (Perilla frutescens Britton var. acuta Kudo) Leaves in Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2026;18(6):960. PubMed PMID: 41901135
2. Hashimoto M, Matsuzaki K, Kato S, Hossain S, Ohno M, Shido O. Twelve-month Studies on Perilla Oil Intake in Japanese Adults-Possible Supplement for Mental Health. Foods. 2020;9(4):530. PubMed PMID: 32331363
3. Hashimoto M, Matsuzaki K, Hossain S, Ito T, Wakatsuki H, Tanabe Y, et al. Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential. Foods. 2021;10(5):1130. PubMed PMID: 34069601
4. Hashimoto M, Matsuzaki K, Maruyama K, Hossain S, Sumiyoshi E, Wakatsuki H, et al. Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly. Food Funct. 2022;13(5):2768-2781. PubMed PMID: 35171190
5. Hashimoto M, Matsuzaki K, Maruyama K, Sumiyoshi E, Hossain S, Wakatsuki H, et al. Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health. Food Funct. 2022;13(13):7226-7239. PubMed PMID: 35722977
6. Kamalashiran C, Sriyakul K, Pattaraarchachai J, Muengtaweepongsa S. Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial. Curr Alzheimer Res. 2019;16(2):146-155. PubMed PMID: 30543172
7. Ogawa T, Sawane K, Ookoshi K, Kawashima R. Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults. Nutrients. 2023;15(6):1499. PubMed PMID: 36986229
8. Sala-Vila A, Fleming J, Kris-Etherton P, Ros E. Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition. Adv Nutr. 2022;13(5):1584-1602. PubMed PMID: 35170723
9. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr. 2002;88(4):355-63. PubMed PMID: 12323085
10. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88(4):411-20. PubMed PMID: 12323090
11. Lee S, Kim KJ, Park MJ, Park SY, Kim YJ, Yoo H, et al. Effects of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled, parallel trial. Food Funct. 2026;17(12):5394-5409. PubMed PMID: 42132779
12. Baba S, Osakabe N, Natsume M, Yasuda A, Muto Y, Hiyoshi K, et al. Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. Eur J Nutr. 2005;44(1):1-9. PubMed PMID: 15309457
13. Lee AY, Hwang BR, Lee MH, Lee S, Cho EJ. Perilla frutescens var. japonica and rosmarinic acid improve amyloid-β25-35 induced impairment of cognition and memory function. Nutr Res Pract. 2016;10(3):274-81. PubMed PMID: 27247723
14. Takeda H, Tsuji M, Matsumiya T, Kubo M. Identification of rosmarinic acid as a novel antidepressive substance in the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba). Nihon Shinkei Seishin Yakurigaku Zasshi. 2002;22(1):15-22. PubMed PMID: 11917505
15. Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, et al. Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull. 2008;31(7):1376-80. PubMed PMID: 18591778
16. Kwon H, Lee J, Lee E, Moon S, Cho E, Jeon J, et al. Anti-Neuroinflammation Effect of Standardized Ethanol Extract of Leaves of Perilla frutescens var. acuta on Aβ-Induced Alzheimer's Disease-like Mouse Model. Pharmaceutics. 2025;17(8):1045. PubMed PMID: 40871065
17. Lee J, Lee E, Kwon H, Moon S, Bae HJ, Hwang JH, et al. Synaptic Plasticity-Enhancing and Cognitive-Improving Effects of Standardized Ethanol Extract of Perilla frutescens var. acuta in a Scopolamine-Induced Mouse Model. Int J Mol Sci. 2025;26(20):9925. PubMed PMID: 41155218
18. Zhao G, Yao-Yue C, Qin GW, Guo LH. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiol Aging. 2012;33(1):176-86. PubMed PMID: 20382451
19. Zhao G, Qin GW, Wang J, Chu WJ, Guo LH. Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt. Neurochem Int. 2010;56(1):168-76. PubMed PMID: 19815045
20. Ryu D, Jee HJ, Kim SY, Hwang SH, Pil GB, Jung YS. Luteolin-7-O-Glucuronide Improves Depression-like and Stress Coping Behaviors in Sleep Deprivation Stress Model by Activation of the BDNF Signaling. Nutrients. 2022;14(16):3314. PubMed PMID: 36014820
21. Jeefoo WP, Thongrong S, Kangwan N, Pohsa S, Kangwan J, Kobroob A, et al. Protective effects of Perilla frutescens seed oil on cognitive function, oxidative stress and acetylcholinesterase activity in a D-galactose-induced accelerated aging model in rats. Biomed Rep. 2026;24(6):76. PubMed PMID: 42125765
22. Ahmed HM. Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt. Molecules. 2018;24(1):102. PubMed PMID: 30597896
23. Jeong YY, Park HS, Choi JH, Kim SH, Min KU. Two cases of anaphylaxis caused by perilla seed. J Allergy Clin Immunol. 2006;117(6):1505-6. PubMed PMID: 16751022
24. Jeong K, Lee SY, Jeon SA, Gantulga P, Nam JY, Hong SJ, et al. Clinical and Immunological Characterization of Perilla Seed Allergy in Children. J Investig Allergol Clin Immunol. 2023;33(1):14-20. PubMed PMID: 34643183
25. Ramírez-Mateo E, Elías-Sáenz I, Fernández-Lozano C, Carrón-Herrero A, Solano-Solares E, González-De-Olano D. Allergy to White Perilla and Cross-reactivity With Sesame. J Investig Allergol Clin Immunol. 2024;34(6):421-423. PubMed PMID: 39319540

PubMed Topic Searches

1. PubMed: perilla and cognitive function trials
2. PubMed: perilla seed oil and cognition in older adults
3. PubMed: rosmarinic acid and memory in animal studies
4. PubMed: alpha-linolenic acid conversion to docosahexaenoic acid
5. PubMed: perilla seed allergy

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Connections

• Perilla — Benefits Deep Dive — the hub for the Perilla benefit articles
• Perilla (Perilla frutescens) — the main topic page
• Perilla Seed Oil: Plant Omega-3 — composition, conversion and oxidation
• Perilla: Perilla Ketone, Species and Safety — chemotypes and the livestock toxin
• Perilla for Allergy and Seasonal Rhinitis — the other rosmarinic-acid trial
• Luteolin for Brain Health and Neuroinflammation — luteolin from all sources
• Walnuts: Alpha-Linolenic Acid and Brain Health — the same plant omega-3 in a whole food
• Rosemary for Cognitive Function and Memory — another rosmarinic-acid herb
• Lemon Balm for Cognitive Function — another mint-family herb studied for cognition
• Dementia — the condition the Thai trial studied

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