Thoracic Endometriosis and Catamenial Pneumothorax

Endometriosis is usually described as a disease of the pelvis: tissue similar to the lining of the womb growing on the ovaries, the tubes and the pelvic walls. In a small number of women the same kind of tissue is found much higher up — on the diaphragm, on the thin membranes that line the chest (the pleura) or inside the lung itself. When it causes trouble there, the result can be a collapsed lung, bleeding into the chest or coughing up blood, often in step with the menstrual period. This page explains what the research reports about this chest form of the disease: what it is, how often it turns up among women with a collapsed lung, the explanations that have been proposed, how it is diagnosed, and what surgery and hormonal treatment have achieved in published series. The general picture of the disease is on the Endometriosis page, and collapsed lung in general on the Pneumothorax page.

Table of Contents

  1. Endometriosis Above the Diaphragm
  2. The Forms Thoracic Endometriosis Takes
  3. Catamenial Means Timed to the Period
  4. Who the Series Describe
  5. How Often It Is Found Among Women With a Collapsed Lung
  6. Proposed Mechanisms
  7. How the Diagnosis Is Made
  8. What Surgery Finds and Does
  9. Hormonal Suppression After Surgery
  10. Recurrence Figures Side by Side
  11. Fertility Treatment After Catamenial Pneumothorax
  12. What Is Not Known
  13. Key Research Papers
  14. Connections
  15. Featured Videos

Endometriosis Above the Diaphragm

Thoracic endometriosis syndrome (TES) is the name used for endometriosis found in the chest. A 2024 review by Nezhat and colleagues describes thoracic endometriosis syndrome as endometriosis found in the lung tissue, the pleura and the diaphragm — the dome-shaped muscle that separates the chest from the abdomen. The tissue is described as endometrium-like: it is not the lining of the womb itself, but it carries glands and supporting tissue (stroma) that look and behave like it.

That behaviour is the key to the condition. A 2014 pathology study from Paris by Legras and colleagues examined the chest tissue of women operated on for a collapsed lung. Every case of thoracic endometriosis in that series was positive for progesterone and/or estrogen receptors, the docking sites for the two main ovarian hormones. In other words, the tissue in the chest responds to the same monthly hormonal signals as the lining of the womb.

The same 2024 review concludes that thoracic endometriosis syndrome “appears to be a marker of severe endometriosis.” A 2025 radiology review by Xiao and colleagues puts the background in numbers: endometriosis affects about 10% of people of reproductive age assigned female at birth, and it only rarely involves the chest and diaphragm.

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The Forms Thoracic Endometriosis Takes

Reviews describe four well-recognized forms, plus less common ones. A 2014 review in the Journal of Thoracic Disease by Visouli and colleagues calls catamenial pneumothorax the most common form, and lists the others:

The 2024 review by Nezhat and colleagues adds that thoracic endometriosis syndrome may cause no symptoms at all, or may show up as chest pain or shoulder pain alone.

The oldest large summary, a 1996 analysis of 110 published cases by Joseph and Sahn, gave the relative frequency of the four main forms:

A much larger 2024 systematic review by Nikolettos and colleagues, covering 592 published patients from 202 studies between 1950 and March 2024, found catamenial pneumothorax to be the most common presentation at 68.4%.

A rarer complication is a hole in the diaphragm large enough for abdominal organs to pass into the chest. A 2024 surgical series by Bobbio and colleagues described 20 women (median age 36) operated on for an endometriosis-related diaphragmatic hernia over twenty years at one centre. The hernia was found together with an endometriosis-related pneumothorax in 13 of them and while investigating period-timed chest pain in the other seven. Eighteen were on the right side, and the median hernia diameter was 8 cm.

Sudden one-sided chest pain with breathlessness is the typical start of a collapsed lung, and hospitals treat it as urgent whatever the cause; the warning signs and emergency care are described on the Pneumothorax page.

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Catamenial Means Timed to the Period

“Catamenial” comes from the Greek for “monthly” and simply means linked to menstruation. The 2014 review by Visouli and colleagues states that the lung usually collapses less than 72 hours after the period starts. A 2026 imaging review by Lojanica and colleagues describes the window as most commonly within 72 hours before or after the onset of menstruation. The diagnosis is clinical as much as anatomical: the pattern of repeated collapses lining up with the cycle is itself the main clue.

The other striking pattern is the side. Joseph and Sahn found the right side of the chest involved in more than 90% of all forms except nodules. In the 2024 review of 592 patients, lesions were found mainly in the right lung alone (79.9%). In the 2005 Philadelphia series by Marshall and colleagues, every one of eight period-timed pneumothoraces was on the right. The right-sided pattern is one of the observations the diaphragm-based explanations described further down try to account for.

Pain sometimes comes first. In a 2011 study of 156 women operated on for spontaneous pneumothorax, Rousset-Jablonski and colleagues found that over a quarter of the women with catamenial or endometriosis-related pneumothorax had a previous history of recurring chest or shoulder-blade pain during their periods. The authors describe this pain as often preceding the pneumothorax and as highly specific for thoracic endometriosis.

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Who the Series Describe

The published series describe women of reproductive age, most in their thirties.

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How Often It Is Found Among Women With a Collapsed Lung

Catamenial pneumothorax is often described as rare. Series from surgical centres that look for it carefully report much higher figures among women referred for an operation on a spontaneous pneumothorax (one with no injury behind it). The numbers differ widely, mainly because the centres used different definitions and different ways of asking about the cycle:

The Heidelberg authors explain their lower figure themselves: a link with the period was documented in 57.1% of their catamenial cases, while in 35.7% no one had asked. They conclude that catamenial pneumothorax is likely underdiagnosed in surgical series of women with spontaneous pneumothorax, and that the main limitation is incomplete history-taking rather than a lack of findings at operation.

All of these figures come from women sent to a surgical centre, who tend to have repeated or difficult collapses. They do not tell how often thoracic endometriosis lies behind a collapsed lung in women in general.

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Proposed Mechanisms

No single explanation has been proven, and the papers present their explanations as hypotheses. The ones that appear in the studies read for this page are:

How an implant on the lung or diaphragm leads to air entering the chest at the time of the period is not settled in these papers. Lesions on the lung surface, holes in the diaphragm, and blebs (small air blisters) are all found in different women, and some women have none of them.

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How the Diagnosis Is Made

The diagnosis rests on three things put together: the history, the findings at operation, and examination of removed tissue under the microscope.

The history. The 2014 review by Visouli and colleagues notes that the diagnosis can be hinted at by repeated collapses in a woman of reproductive age with endometriosis, and that the blood marker cancer antigen 125 (CA-125) is raised. The Heidelberg authors argue that systematically asking about the timing of each collapse in relation to the period is the step most often missed.

Imaging. A 2026 review by Lojanica and colleagues describes chest X-ray and computed tomography (CT) as useful for documenting the acute event, such as a collapse or blood in the chest, but finds imaging often nonspecific and unable to make the diagnosis on its own. The 2024 systematic review found ground-glass nodules and cystic lesions to be the most common CT findings. The 2025 radiology review by Xiao and colleagues argues that magnetic resonance imaging (MRI) shows soft tissue and blood products better than X-ray or CT, and describes a dedicated MRI protocol for the diaphragm: images in two extra planes to follow its dome shape, breath-holding to limit motion blur, and sequences that make blood products and small fluid-filled spots stand out.

Thoracoscopy. The 2014 review names video-assisted thoracoscopy (keyhole surgery of the chest) or medical thoracoscopy as the way the diagnosis is confirmed. Surgeons describe looking in particular at the diaphragm. The findings reported are endometrial implants and small holes (perforations or fenestrations) in the diaphragm. A 2004 Zurich report by Korom and colleagues describes three women whose earlier keyhole operations had not stopped their collapses; at a later operation, multiple small perforations in the tendinous part of the right diaphragm, with nearby endometrial implants, were found. The authors stress that inspection of the diaphragm during the operation is paramount.

Tissue under the microscope. Confirmation under the microscope is often missing even when the operation shows suggestive findings. In the Heidelberg series, findings at operation suggested thoracic endometriosis in 85.7% of women with catamenial pneumothorax, but tissue confirmation was achieved in only 14.3%. In the 2014 Paris pathology study, the features that independently pointed to thoracic endometriosis were right-sided pneumothorax, abnormalities of the diaphragm, a return of the collapse after surgery on one side, and iron-laden cells left behind by old bleeding (hemosiderin-laden macrophages). Emphysema-like changes at the top of the lung were found in 86% of the women who had that area removed, and they were linked with the absence of thoracic endometriosis.

Diagnostic delay in endometriosis in general is discussed on the Diagnosis Delay and Imaging page.

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What Surgery Finds and Does

Surgery for catamenial pneumothorax is usually video-assisted thoracoscopic surgery (VATS), done through small cuts in the side of the chest. The published series describe three main parts to the operation:

What the surgeons find varies. In the 2003 prospective study, all eight women with catamenial pneumothorax had diaphragm abnormalities: holes alone in one, implants alone in three, and both in four. Diaphragmatic endometriosis was confirmed under the microscope in seven of the eight. Korom and colleagues’ 2004 literature review of 229 published cases found thoracic endometriosis diagnosed in 73 of the 140 operated women with detailed findings (52.1%), and diaphragm lesions in 54 (38.8%); pleurodesis, with or without diaphragm repair or removal of a wedge of lung, was performed in 81.7% of cases. The 2017 systematic review by Bricelj and colleagues, covering 182 patients operated on since keyhole chest surgery began, found endometrial implants in 59.3%, diaphragm perforations in 57.0%, and no abnormality at all in 2.9%.

The 2026 systematic review by Mekhail and colleagues, covering 37 studies and more than 1,800 patients, highlights the diaphragm. One included study reported recurrence in 12.5% when diaphragm surgery was combined with pleurodesis, against 100% with pleurodesis alone. Another found that diaphragm resection was an independent protective factor against recurrence (hazard ratio 0.16).

Surgery carries its own burden. A 2026 meta-analysis by Amin and colleagues of 28 studies and 1,182 operated patients with thoracic endometriosis syndrome found an overall complication rate of 30.8%, a prolonged air leak in 24.2%, chest drains in place for an average of 4.4 days and an average hospital stay of 6.1 days. The 2024 review by Nezhat and colleagues describes managing thoracic endometriosis syndrome conservatively as far as possible, with surgery reserved for cases that do not respond, sometimes combining chest keyhole surgery with laparoscopy of the abdomen. The wider debate on surgery for pelvic disease is on the Laparoscopy: Excision vs Ablation page.

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Hormonal Suppression After Surgery

Because the chest implants respond to ovarian hormones, many centres add hormonal treatment that stops or quiets the menstrual cycle. The 2024 systematic review lists the drug groups used: gonadotropin-releasing hormone (GnRH) analogues, progestins, androgens and combined oral contraceptives, mostly together with surgery and sometimes on their own. How these drug groups work in endometriosis generally is described on the Hormonal Therapy Options page.

The Mekhail review concludes that surgery addressing the diaphragm, combined with pleurodesis and hormonal therapy after the operation, is consistently associated with reduced recurrence, while warning that the data are observational and are to be interpreted with caution.

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Recurrence Figures Side by Side

Catamenial pneumothorax is known for coming back, even after an operation. The figures below show how much the reported rates vary with the kind of study and the treatment given:

The Bricelj review sums it up: keyhole chest surgery gives good diagnostic and treatment results, but about one in four patients had a recurrence despite adequate treatment.

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Fertility Treatment After Catamenial Pneumothorax

Infertility is common in this group, and fertility treatment raises hormone levels sharply, which raises the question of whether it can set off a collapse. A 2026 case series from Paris by Fornelli and colleagues followed 11 women aged 18 to 43 whose catamenial pneumothorax had been treated with surgery, and who had assisted reproductive technology (ART) before and/or after their chest operation.

The authors call for prospective studies; eleven women is too few to estimate the risk with confidence. Fertility planning in endometriosis is covered on the Fertility and Endometriosis page.

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What Is Not Known

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Key Research Papers

  1. Joseph J, Sahn SA. Thoracic endometriosis syndrome: new observations from an analysis of 110 cases. Am J Med. 1996;100(2):164-70. PubMed PMID: 8629650
  2. Alifano M, Roth T, Broët SC, Schussler O, Magdeleinat P, Regnard JF. Catamenial pneumothorax: a prospective study. Chest. 2003;124(3):1004-8. PubMed PMID: 12970030
  3. Korom S, Canyurt H, Missbach A, Schneiter D, Kurrer MO, Haller U, Keller PJ, Furrer M, Weder W. Catamenial pneumothorax revisited: clinical approach and systematic review of the literature. J Thorac Cardiovasc Surg. 2004;128(4):502-8. PubMed PMID: 15457149
  4. Marshall MB, Ahmed Z, Kucharczuk JC, Kaiser LR, Shrager JB. Catamenial pneumothorax: optimal hormonal and surgical management. Eur J Cardiothorac Surg. 2005;27(4):662-6. PubMed PMID: 15784370
  5. Rousset-Jablonski C, Alifano M, Plu-Bureau G, Camilleri-Broet S, Rousset P, Regnard JF, Gompel A. Catamenial pneumothorax and endometriosis-related pneumothorax: clinical features and risk factors. Hum Reprod. 2011;26(9):2322-9. PubMed PMID: 21685141
  6. Legras A, Mansuet-Lupo A, Rousset-Jablonski C, Bobbio A, Magdeleinat P, Roche N, Regnard JF, Gompel A, Damotte D, Alifano M. Pneumothorax in women of child-bearing age: an update classification based on clinical and pathologic findings. Chest. 2014;145(2):354-360. PubMed PMID: 24091546
  7. Visouli AN, Zarogoulidis K, Kougioumtzi I, Huang H, Li Q, Dryllis G, et al. Catamenial pneumothorax. J Thorac Dis. 2014;6(Suppl 4):S448-60. PubMed PMID: 25337402
  8. Bricelj K, Srpčič M, Ražem A, Snoj Ž. Catamenial pneumothorax since introduction of video-assisted thoracoscopic surgery: a systematic review. Wien Klin Wochenschr. 2017;129(19-20):717-726. PubMed PMID: 28762057
  9. Tsuboshima K, Kurihara M, Okumura G, Ohashi K, Takahashi K, Shiko Y, Ozawa Y, Seyama K. Postoperative hormonal therapies reduce the recurrence of thoracic endometriosis-related pneumothorax. Eur J Cardiothorac Surg. 2023;64(4):ezad331. PubMed PMID: 37773983
  10. Nikolettos K, Patsouras A, Kotanidou S, Garmpis N, Psilopatis I, Garmpi A, et al. Pulmonary endometriosis: a systematic review. J Pers Med. 2024;14(11):1085. PubMed PMID: 39590577
  11. Bobbio A, Gherzi L, Tormen F, Sion A, Prieto M, Daffre E, Fournel L, Alifano M. A surgical series on endometriosis-related diaphragmatic hernia. Gen Thorac Cardiovasc Surg. 2024;72(10):668-673. PubMed PMID: 38461451
  12. Nezhat C, Amirlatifi N, Najmi Z, Tsuei A. Thoracic endometriosis syndrome: a comprehensive review and multidisciplinary approach to management. J Clin Med. 2024;13(24):7602. PubMed PMID: 39768527
  13. Xiao L, White D, Kruger LF, Alwatari Y, Blackmon S, Burnett T, Khan Z, Chamié LP, Feldman M, VanBuren W. Thoracic endometriosis syndrome: imaging findings and the value of a dedicated MRI protocol. Abdom Radiol (NY). 2025;50(9):4423-4436. PubMed PMID: 39964372
  14. Amin A, Baryshnikov I, Shafique MA, Naruka V, Kajitani S, Chavan H, Hirsch M, Hallifax RJ, Asadi N. Thoracic endometriosis syndrome: a systematic review and meta-analysis of surgical outcomes among 1,182 patients over 25 years. J Minim Invasive Gynecol. 2026;33(5):546-556. PubMed PMID: 41419079
  15. Mekhail A, Kilby J, Macalister S, Manivannan PC, Seitz M. Surgical management of catamenial pneumothorax: a systematic review. J Cardiothorac Surg. 2026;21(1):433. PubMed PMID: 42063108
  16. Lojanica MV, Ivanovic S, Milic N, Jovic N, Rakic N, Pilic I, et al. Thoracic endometriosis and catamenial pneumothorax: imaging pitfalls and an integrated diagnostic approach. J Clin Med. 2026;15(12):4517. PubMed PMID: 42355685
  17. Deissner H, Niedermaier B, Griffo R, Wimmer C, Polke M, Trudzinski FC, et al. Catamenial pneumothorax as an underrecognized manifestation of thoracic endometriosis: a 25-year single-center experience. J Clin Med. 2026;15(13):4941. PubMed PMID: 42452403
  18. Fornelli G, Bourdon M, Maignien C, Melka L, Gherzi L, Mantelet LM, Patrat C, Somigliana E, Alifano M, Santulli P. Assisted reproductive technology in women with endometriosis and a history of catamenial pneumothorax: reproductive outcomes and safety considerations. J Minim Invasive Gynecol. 2026;33(7):955-962. PubMed PMID: 41633483

PubMed Topic Searches

  1. PubMed: catamenial pneumothorax
  2. PubMed: thoracic endometriosis syndrome
  3. PubMed: diaphragmatic endometriosis
  4. PubMed: catamenial hemoptysis
  5. PubMed: hormonal therapy and recurrence in thoracic endometriosis

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Connections

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