Protocols & Practices
The Protocols (13)
Longevity Protocols
The overview: what the approaches grouped as longevity protocols propose, and what trials tested and found
Read the deep dive →Exercise
Physical activity and fitness: among the most consistent human data linked with longer life, mostly from observational studies
Read the deep dive →Fasting
Time-restricted eating to extended fasts, and the autophagy research behind them
Read the deep dive →Caloric Restriction
Lifespan gains in laboratory animals, and what the human CALERIE trial measured
Read the deep dive →Senolytics
Drugs designed to clear senescent cells, and the small human trials so far
Read the deep dive →Rapamycin
The transplant drug that extended lifespan in mice; human trials measure biomarkers, not lifespan
Read the deep dive →Metformin
The diabetes drug proposed for aging; the TAME trial has published no results
Read the deep dive →Sauna
The Finnish cohort data on sauna bathing and mortality: an association, not a trial result
Read the deep dive →Cold Exposure
Cold-water immersion and brown fat: what studies measured
Read the deep dive →Red Light Therapy
Photobiomodulation: where evidence is real and where it thins
Read the deep dive →Sleep Hygiene
Sleep duration, sleep stages, and what studies link them with
Read the deep dive →Stress Management
Cortisol, telomeres, and what trials of stress-reduction practices found
Read the deep dive →Brain Aging
What research reports on cognitive aging and the factors linked with it
Read the deep dive →The practices, drugs and programmes discussed in longevity research, each with its own page reporting what named people or programmes propose and what trials tested and found. No protocol, practice or drug on this list has been shown to extend human lifespan. The most consistent human data, mostly from long observational studies, link physical activity, adequate sleep, maintained muscle mass and not smoking with longer life; the sauna data come from a Finnish cohort and show an association, not a trial result. Rapamycin, a transplant drug, and metformin, a diabetes drug, are studied for aging: rapamycin's lifespan results are mouse results, and the TAME trial of metformin, proposed in 2016, has published no results. The tiers of evidence are set out in The Honest Picture.
Connections
- Longevity — The section hub with all sub-pages
- Antioxidants — The full compound library behind the molecules above
- Natural Medicine — All practices, protocols, and therapies
- Amino Acids — Taurine, glycine, creatine, collagen, and the rest
- Mushrooms — Ergothioneine's richest food source
- Gut Health — The microbiome's role in healthy aging
- Food — Whole-food sources beat capsules where both exist
- Biology — All 137 interactive animations
- Vitamins — Including vitamin D and the B-complex aging essentials
- Notable Doctors — The researchers and clinicians behind the science