Nicotine: The Research

Table of Contents

1. Research at a Glance
2. By Topic
3. By Condition
4. Newest in the Collection
5. How This Collection Is Built
6. Connections
7. Featured Videos

Research at a Glance

How many papers each page lists, and how much of the collection is research in people rather than in cells or animals. Hover over a bar for its count.

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By Topic

556 papers in the collection so far, updated weekly. A paper that fits more than one page is listed on each.

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By Condition

The conditions most often discussed with nicotine, each with its own research page.

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Newest in the Collection

1. Psychological distress, perceived psychological reward, and nicotine dependence among young people (2026, human observational study) — Mood and Mental Health
2. Nicotine metabolites generate craniofacial defects that are worsened by ethanol exposure (2026, animal study) — Metabolites and Chemistry
3. Nicotine self-administration suppresses both pro- and anti-inflammatory accumbens cytokines but does not induce apoptosis in female rats (2026, animal study) — Inflammation and Immunity
4. Tobacco Use Disorder and Co-Occurring Mental Health Conditions: Considerations for Future DSM (2026, review) — Mood and Mental Health
5. Protective effects of nicotine with or without PPAR-γ inhibition in saline lavage-induced lung injury in rats (2026, animal study) — Inflammation and Immunity
6. Ionotropic Glutamate Receptor Function in Interpeduncular Nucleus Is Modulated by Nicotine Exposure (2025, animal study) — Mood and Mental Health
7. Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice (2022, animal study) — Arthritis and Pain
8. Nicotine binds to the transthyretin-thyroxine complex and reduces its uptake by placental trophoblasts (2022, cell study) — Thyroid and Hashimoto's
9. Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis (2022, cell study) — Arthritis and Pain
10. Nicotine-induced C-shape movements in planarians are reduced by antinociceptive drugs: Implications for pain in planarian paroxysm etiology? (2022, animal study) — Arthritis and Pain
11. Bufotenine and its derivatives: synthesis, analgesic effects identification and computational target prediction (2021, animal study) — Arthritis and Pain
12. Cigarette Smoking and Estrogen-Related Cancer (2021, review) — Thyroid and Hashimoto's

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How This Collection Is Built

1. Each page runs its own PubMed search for papers in which nicotine is a major subject and that have an abstract. The search is linked at the bottom of every page.
2. Each paper’s record — title, authors, journal, year, PMID and DOI — is taken from PubMed itself, never typed by hand, and retracted papers are skipped.
3. The plain-language summary is written from the paper’s own abstract, keeping its numbers and saying whether the work was in cells, animals or people. Papers that only use nicotine as a marker of smoking are left out.
4. New papers are added every week, and the newest appear at the top of each page.

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Connections

• The Neuromuscular Junction: How a Nerve Commands a Muscle — interactive animation
• Medicines and Oils
• The Nicotine Patch, animated — how a patch, gum and a cigarette differ in the blood
• Dr. Bryan Ardis — his nicotine claims, documented on their own pages
• Nicotinic Acetylcholine Receptors
• Cigarette Smoke — what burnt tobacco adds that nicotine alone does not
• Vitamin B3 (Niacin) — named after nicotinic acid, an oxidation product of nicotine, but a different molecule

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