My Healthcare News & Research — January 26, 2026 · Plastics’ Life Cycle Could Cost 83 Million Healthy Years

On January 26, 2026, the journal The Lancet Planetary Health published online what its authors describe as the first global-scale estimate of the healthy years of life lost to the gases and chemicals released across the life cycle of plastics: from the oil and gas wells that supply their raw materials, through the plants that make the polymers, to the landfills, incinerators, dumps and open fires where much of it ends up. The team, led from the London School of Hygiene & Tropical Medicine with co-authors in Toulouse and at the University of Exeter, calculated that under “business as usual” the plastics in their model were associated with a cumulative 83 million disability-adjusted life-years (DALYs) worldwide between 2016 and 2040, with the yearly total rising from 2.1 million DALYs in 2016 to 4.5 million in 2040.

This is a modelling study, not a study of patients. No one was examined, tested or followed. The researchers combined an existing model of where the world’s plastic goes each year with a lifecycle assessment, a standard accounting method that lists what is released at each step of a product’s life and converts those releases into estimated health damage. The model covers the plastics commonly found in household and municipal waste, which the paper puts at about 64% of global plastics production. It leaves out two exposures many readers associate most with plastics: chemicals released from products while they are being used, and microplastics and nanoplastics, because the data needed to model them do not exist.

This archive report sets out what the paper itself states: how the model was built, each main number with its uncertainty, what the authors say it cannot show, and how it sits beside earlier research on plastic chemicals and microplastics. Every figure is taken from the open-access full text, not from press coverage. Where coverage went further than the paper, that is noted.

Table of Contents

  1. At a Glance
  2. Life-Cycle Models and DALYs Explained
  3. What Was Done
  4. What Was Found, Number by Number
  5. Where the Modelled Harm Comes From
  6. How It Fits With Earlier Research
  7. What It Cannot Show
  8. What the Authors and Coverage Said
  9. What Remains Unknown
  10. Sources and Primary Documents
  11. Key Research Papers
  12. Connections

At a Glance

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Life-Cycle Models and DALYs Explained

A lifecycle assessment works like an accounting ledger for a material. For each step in a product’s life, analysts list the inputs (energy, raw materials, transport) and the outputs (greenhouse gases, fine particles, metals and other chemicals released to air, water and soil). That list is called an inventory. A published impact method then converts each release into an estimated health effect, using factors drawn from earlier research on how, for example, a tonne of a given air pollutant translates into heart and lung disease across a population. The method used here follows the international ISO 14040 and 14044 standards.

For plastics, the steps in this model were:

The steps in which plastic is shaped into products and then used by consumers were not part of the underlying flow model, so they sit outside this study’s boundary.

A material flow analysis supplies the other half: how many tonnes of plastic move through each step each year, in each kind of region, under each future scenario. The team multiplied those tonnages by their estimated health damage per million tonnes to get a health total for every year.

A DALY (disability-adjusted life-year) is a standard measure of disease burden. In the paper’s words, “one DALY represents 1 year of healthy life lost in a population due to the sum of morbidity and premature mortality associated with a given disease.” It adds together years lived with illness or disability and years lost to early death, so a figure of 83 million DALYs means an estimated 83 million years of healthy life lost across the world’s population. It is not a count of people or deaths. The impact method used, called ReCiPe 2016, applies no age weighting or discounting and looks 100 years ahead from the moment of each release. A given year’s DALYs therefore include future harm from that year’s releases, such as cancers linked to substances that leak from landfills over very long periods.

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What Was Done

The study builds on the Plastics-to-Ocean (P2O) model, published in Science in 2020, which tracked the flow of municipal solid-waste plastics from production to end of life between 2016 and 2040. P2O covers plastic packaging, single-use products, nappies and sanitary waste, cigarette butts, durable consumer products, household products and business-to-business packaging. It excludes medical, hazardous, electronic, textile, agricultural, transport and construction waste and other industrial waste. It sorts plastic into three broad categories (rigid single materials, flexible single materials, and multilayer or mixed materials) and the world into eight regional “archetypes” by income level (high, upper-middle, lower-middle, low) and by rural or urban setting.

The P2O model defines six global scenarios, which this study carried over unchanged:

To turn P2O’s product categories into chemistry, the team estimated which polymers make up each product type from published literature. They then compiled inventories of short-term and long-term releases for each polymer at each step, mainly from the Ecoinvent database (versions 3.8 and 3.10), adjusted each region’s electricity mix (its reliance on fossil fuels, nuclear and renewables), and converted the releases into DALYs with the ReCiPe 2016 method, updated with the Intergovernmental Panel on Climate Change’s 2021 warming factors.

Substitutes were modelled as illustrations. Paper, coated paper and polylactide (a bio-based plastic) were assumed to replace plastic at a 1:1 ratio by weight, with paper recycled at 75% and polylactide fully incinerated, choices the authors made to show the larger potential gains. Because published replacement ratios vary widely, they repeated the 2040 calculation with ratios from 0.4 to 9.0 for paper-based substitutes and 0.8 to 1.4 for compostables. They also designed two reusable-glass systems for food packaging: reuse inside the home, and door-to-door refill delivery.

On uncertainty, the paper states that “statistical evaluation of summative uncertainty was not feasible or meaningful for these illustrative analyses.” The confidence intervals it reports come from 300 earlier P2O simulations of plastic flows. They describe uncertainty in how much plastic goes where, not in the health conversion factors or the inventories.

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What Was Found, Number by Number

The starting year, 2016

Business as usual, 2016 to 2040

Under business as usual the model gave a cumulative 83 million DALYs over 2016–2040, rising each year to 4.5 million DALYs in 2040 (95% CI 4.4–4.7 million). The paper attributes the rise to the projected growth in plastics demand, with no change in policy, infrastructure, economics, materials or behaviour, and states that health effects “more than doubled” over the period. The shares from each stage and each health pathway were similar in 2016 and 2040.

The six scenarios, cumulative 2016–2040

The year 2040

What drove the differences

What remained in the best case

In the 2040 system change scenario, primary petrochemical plastics production was still the leading source (63%, 1.9 million DALYs), followed by polylactide alternatives (12%, 0.4 million), open burning (5%, 0.2 million), chemical recycling (5%, 0.1 million) and industrial incineration (4%, 0.1 million). Paper, coated paper and the two reusable-glass systems each contributed 1–2% (0.03–0.05 million DALYs), though at higher substitution ratios paper-based substitutes could reach 11% (0.4 million). In the household glass-reuse system, home washing accounted for 94–98% of its health effects.

The paper’s summary of the scenarios: “Reducing primary plastics production, without material substitution, was the most effective single lever for reducing emissions and alleviating associated health burdens.”

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Where the Modelled Harm Comes From

The paper found that every stage of the plastics life cycle generated releases linked to harm, mainly through three routes:

The same amount of plastic produced different health totals in different regions, largely because of differences in regional electricity mixes. The paper reports greater adverse effects in lower-middle-income archetypes for the same processes.

What the model does not trace is the route most people picture: chemicals such as phthalates, bisphenols, PFAS and flame retardants moving from plastic products into food, drink, dust and the body, and particles of plastic lodging in tissues. The authors write that it is “unclear to what extent chemicals contained in plastics are captured at other stages of the plastics lifecycle because of a crucial absence of transparency in available data inventories.”

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How It Fits With Earlier Research

The paper draws on, and sits beside, several lines of earlier work:

The paper notes that an earlier lifecycle analysis built on economic projections from the Organisation for Economic Co-operation and Development estimated toxic effects and ozone-related health effects of the global plastics system for 2019 and 2060, but did not compare alternative scenarios or include fine particles and climate change. The authors present their study as the first to bring all the relevant health indicators of lifecycle assessment together at global scale.

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What It Cannot Show

The authors are direct about the status of their numbers: “Our results should not be interpreted as predictions but as quantitative illustrations of potential health effects across plastics lifecycles and global scenarios.” The main limits they list are these:

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What the Authors and Coverage Said

The paper’s interpretation states that “adverse health effects are associated with emissions throughout plastics lifecycles, particularly from production, though the non-disclosure of plastics chemical composition is severely limiting LCA capacity to inform effective policy.” The authors call for deep reductions in primary production within plastics roadmaps, for assessments that include use-stage exposure, chemicals, microplastics and nanoplastics, and for “mandatory transparency and reporting,” and conclude that “globally coordinated policy that addresses these upstream impacts through a full lifecycle approach is crucial to protecting human health.” The paper notes that the UN Environment Assembly adopted resolution 5/14 in March 2022 to develop a legally binding instrument to end plastics pollution, and that “as of 2026, the future Global Plastics Treaty is under negotiation by more than 175 member states.”

In a report by Agence France-Presse dated January 26–27, 2026, lead author Megan Deeney said of the estimate: “This is undoubtedly a vast underestimate of the total human health impacts.” The same report says she referred to the problem as a “global public health crisis” and said the most effective measure in the model was reducing the amount of “unnecessary” plastic made in the first place.

The AFP report gave the 83 million, 2.1 million and 4.5 million figures, and all three appear in the paper. Some of the coverage checked for this report went further than the paper:

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What Remains Unknown

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Sources and Primary Documents

Every figure attributed to the study above was taken from the open-access full text, not from press coverage. The identifiers were checked against PubMed and Crossref.

  1. Deeney M, Hamelin L, Vialle C, Yan X, Green R, Yates J, Kadiyala S (2026). Global health burdens of plastics: a lifecycle assessment model from 2016 to 2040. The Lancet Planetary Health 10(1):101406. Published online January 26, 2026. — doi:10.1016/j.lanplh.2025.101406 · PubMed PMID: 41610860 · Full text (PMC12867957)
  2. Lau WWY, Shiran Y, Bailey RM, et al. (2020). Evaluating scenarios toward zero plastic pollution. Science 369(6510):1455-1461. The Plastics-to-Ocean model the study builds on. — doi:10.1126/science.aba9475 · PubMed PMID: 32703909
  3. Agence France-Presse (January 27, 2026). Health threat of global plastics projected to soar. — AFP report (GMA News copy)
  4. Common Dreams (January 27, 2026). Coverage of the study. — News report
  5. INRAE, French National Research Institute for Agriculture, Food and Environment (February 23, 2026). Global impact of plastics on healthy living. — Institute news item

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Key Research Papers

Background papers on plastics and health, checked against PubMed and Crossref before they were written down.

  1. Landrigan PJ, Raps H, Cropper M, Bald C, Brunner M, Canonizado EM, et al. (2023). The Minderoo-Monaco Commission on Plastics and Human Health. Annals of Global Health 89(1):23. — PubMed PMID: 36969097
  2. Landrigan PJ, Dunlop S, Treskova M, Raps H, Symeonides C, Muncke J, et al. (2025). The Lancet Countdown on health and plastics. The Lancet 406(10507):1044-1062. — PubMed PMID: 40769171
  3. Fuller R, Landrigan PJ, Balakrishnan K, Bathan G, Bose-O’Reilly S, Brauer M, et al. (2022). Pollution and health: a progress update. The Lancet Planetary Health 6(6):e535-e547. — PubMed PMID: 35594895
  4. Symeonides C, Aromataris E, Mulders Y, Dizon J, Stern C, Barker TH, et al. (2024). An Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals. Annals of Global Health 90(1):52. — PubMed PMID: 39183960
  5. Trasande L, Krithivasan R, Park K, Obsekov V, Belliveau M (2024). Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the United States. Journal of the Endocrine Society 8(2):bvad163. — PubMed PMID: 38213907
  6. Hyman S, Acevedo J, Giannarelli C, Trasande L (2025). Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lost. eBioMedicine 117:105730. — PubMed PMID: 40307157
  7. Marfella R, Prattichizzo F, Sardu C, Fulgenzi G, Graciotti L, Spadoni T, et al. (2024). Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. New England Journal of Medicine 390(10):900-910. — PubMed PMID: 38446676
  8. Thompson RC, Courtene-Jones W, Boucher J, Pahl S, Raubenheimer K, Koelmans AA (2024). Twenty years of microplastic pollution research—what have we learned? Science 386(6720):eadl2746. — PubMed PMID: 39298564

PubMed Topic Searches

  1. PubMed: Plastics, life cycle assessment and human health
  2. PubMed: Plastics and disability-adjusted life-years
  3. PubMed: Plastic-associated chemicals, phthalates, bisphenols and health
  4. PubMed: Microplastics in human tissue and cardiovascular disease
  5. PubMed: Open burning of plastic waste, air pollution and health

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Connections

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