The Riordan Clinic


Orthomolecular Medicine News Service, February 1, 2017
Intravenous Vitamin C Protects Against Metabolic Syndrome and Activates Nrf2
by Nina Mikirova, PhD

(OMNS, Feb 1, 2017) Vitamin C is essential for life in humans, as the capacity to synthesize it has been lost in the course of our evolution. Besides its antioxidant properties and its role in collagen synthesis, vitamin C has been shown to boost the immune system, to markedly lower blood histamine concentrations, and to have antiviral activity. Large epidemiological studies have shown that intake of vitamin C and other antioxidants can protect against hypertension and the symptoms of diabetes mellitus (such as diabetic retinopathy), and can increase high-density lipoprotein (HDL) cholesterol (thought to be protective), and enhance endothelial function.

When vitamin C is infused intravenously at doses of 10,000 milligrams or higher, it can reach 100 times the level in the blood achievable with oral vitamin C. At this very high level, it shows cytotoxicity against some types of cancer cells. Our laboratory wanted to know whether intravenous vitamin C (IVC, 15,000 mg) would alleviate inflammation and metabolic syndrome. If this study showed positive results, this would potentially benefit millions of people world-wide with chronic inflammatory disease.[1]
Metabolic syndrome

Metabolic syndrome or “adiposity” is a chronic accumulation of body fat. Metabolic syndrome is one of the major public health challenges worldwide that is characterized by:

Increased fat around the waist
Elevated blood triglycerides
Decreased HDL cholesterol
Elevated fasting glucose
Elevated blood pressure

These symptoms are associated with chronic diseases such as respiratory and cardiovascular disease, type two diabetes, fatty liver, visceral adiposis, and cancer, which all increase mortality.

Excess fat is associated with chronic low-grade inflammation. Over time this fatty tissue can release signals to the rest of the body that accelerate inflammation. This in large part explains the development of obesity-related disease. Excess fat can also cause insulin resistance and hyperglycemia. It can also trigger atherosclerosis, dyslipidemia (high blood fat levels), high blood pressure, blood clots, and ischemic stroke.

Oxidative stress caused by metabolic syndrome may also play a role in cancer development, as it causes epigenetic changes in gene expression that can promote the development of cancer.
Inflammatory cytokine signals

We wanted to understand the effects of IVC on the expression of cytokines (messenger molecules) involved in inflammation and the immune response, and to determine if IVC helps to reduce inflammation and stimulate the immune response at a genomic level.

IVC treatments increased the ascorbic acid level and the ratio of reduced to oxidized ascorbic acid in blood. This ratio was decreased in participants with a high level of inflammation in subjects with metabolic syndrome, which may be explained by their increased level of oxidative stress.[2] Therefore, the higher the ratio of reduced to oxidized ascorbic acid, the better for treatment. In this regard, vitamin C was considered as a “healing factor” by Irwin Stone.
Inflammation score

Our study showed that after IVC treatment, the “inflammation score,” defined by the level of inflammatory and anti-inflammatory cytokines, was decreased. IVC treatment evidently modulated immunological genes in blood cells, suggesting potential benefits in regulating inflammation and redox potential. Several other markers of inflammation and anti-inflammation associated with metabolic syndrome were improved, which indicated a decreased risk for chronic disease.

This finding is very important because it proved that IVC treatment of metabolic syndrome and low-grade inflammation resulted in a lower “inflammation score,” which is thought to protect against many types of chronic disease.
Nrf2 regulates antioxidants

Our laboratory analyzed the expression after IVC treatment of one of the factors responsible for the enzymes and proteins involved in the stress response.[1]

This was nuclear respiratory factor 2 (Nrf2), a transcription factor that regulates the expression of several enzymes that synthesize antioxidants and detoxifying molecules.[1,3] In addition, Nrf2 enhances the expression of genes involved in cell energy production and maintenance, which are essential for health and longevity.[4] Nrf2 signaling is essential for detoxification of reactive metabolites and reactive oxygen species (ROS). This factor also helps cells to get rid of toxins. The products of Nrf2 signaling enhance protection against molecular damage. Our study showed that after IVC treatment, genes coding for Nrf2 and several other important signaling molecules were up-regulated.[1] This activation of Nrf2, by IVC treatment can protect against age-related degenerative diseases and cancer,

Aging causes a decline in levels of Nrf2 that promotes oxidative damage. This mechanism is involved in many aged-related diseases, such as Parkinson’s, Alzheimer’s, and Huntington’s diseases, and animal models of atherosclerosis.[5-9]

In many disease states, oxidative and/or inflammatory stress has a crucial role. Degenerative and immunological disorders, including atherosclerosis, inflammatory bowel disease, diabetes, rheumatoid arthritis, HIV/AIDS, neurological disorders, sepsis, and many others, affect more than 45 million people worldwide. Though these diseases appear to be very different, the Nrf2 pathway plays an important role in many of them.

Nrf2 is able to prevent disease by suppressing oxidative stress, so interventions that activate Nrf2 would promote longevity, healthy aging and lower cancer incidence. Recent medical research has shown that Nrf2-activating strategies – which can include drugs, foods, dietary supplements, and exercise – can prevent a wide variety of diseases.[10]

Activation of Nrf2 can protect against acute insults to the lung, kidney, brain, liver, eye and heart that are caused by diverse factors including chemical toxins. Nrf2 activation can help to prevent chronic diseases such as diabetes and obesity, and several neurodegenerative diseases. Nrf2 activity improves atherosclerosis, liver inflammation, and fibrosis associated with obesity in a mouse model. It also is known to be important in rheumatoid arthritis. Oxidative stress is significantly involved in cartilage degradation in arthritis; and the presence of a functional Nrf2 gene is essential for maintaining and rebuilding new cartilage.

In summary, the activation of the Nrf2 pathway has been widely accepted as a promising anti-inflammatory treatment for many diseases including cancer.

Our study demonstrated that high dose vitamin C can protect against inflammation in subjects with metabolic syndrome. Our results suggest that the activation of transcription factor Nrf2 by IVC treatment can induce protection against age-related degenerative diseases and cancer.

(Dr. Nina Mikirova is director of research at the Riordan Clinic in Wichita, Kansas. She earned her PhD in physics and mathematics at Moscow State University in Russia. Dr. Mikirova has published more than 40 peer-reviewed papers in the area of nutrients as biological response modifiers, and 50 articles in the field of biomedical effects of solar radiation.)


1. Mikirova N, Scimeca RC. Intravenous high-dose ascorbic acid reduces the expression of inflammatory markers in peripheral mononuclear cells of subjects with metabolic syndrome. Journal of Translational Science. (2016) Volume 2(3):188-195. doi: 10.15761/JTS.1000139

2. Godala MM, Materek-Kuzmierkiewicz I, Moczulski D, et al. Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study. Adv Clin Exp Med. 2016 Jul-Aug;25(4):689-700. doi: 10.17219/acem/41049.

3. Holmström KM, Kostov RV, Dinkova-Kostova AT. The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol. 2016 Dec;1:80-91. doi: 10.1016/j.cotox.2016.10.002.

4. Hawkins KE, Joy S, Delhove JM, Kotiadis VN, et al. NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Rep. 2016 Mar 1;14(8):1883-91. doi: 10.1016/j.celrep.2016.02.003.

5. Pajares M, Cuadrado A, Rojo AI. Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biol. 2017 Jan 10;11:543-553. doi: 10.1016/j.redox.2017.01.006. [Epub ahead of print]

6. Sun Y, Yang T, Leak RK, Chen JH, Zhang F. Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases. CNS Neurol Disord Drug Targets. 2017 Jan 2. [Epub ahead of print]

7. Kowluru RA, Mishra M. Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2. Free Radic Biol Med. 2017 Feb;103:155-164. doi: 10.1016/j.freeradbiomed.2016.12.030.

8. Prasad KN. Oxidative stress and pro-inflammatory cytokines may act as one of the signals for regulating microRNAs expression in Alzheimer’s disease. Mech Ageing Dev. 2016 Dec 10. pii: S0047-6374(16)30291-3. doi: 10.1016/j.mad.2016.12.003. [Epub ahead of print]

9. Handy DE, Loscalzo J. Responses to reductive stress in the cardiovascular system. Free Radic Biol Med. 2016 Dec 8. pii: S0891-5849(16)31090-5. doi: 10.1016/j.freeradbiomed.2016.12.006. [Epub ahead of print]

10. Jiménez-Osorio AS, Gonz lez-Reyes S, Pedraza-Chaverri J. Natural Nrf2 activators in diabetes. Clin Chim Acta. 2015 Aug 25;448:182-92. doi: 10.1016/j.cca.2015.07.009.


The Riordan Clinic

Titanium Dioxide

The Health Supplement Ingredient That Could be Causing Cancer

Titanium dioxide particles have been linked to increased oxidative stress.4 Oxidative stress is a condition characterized by free radical damage within the body that causes cellular instability and chronic inflammation. This state of high oxidative stress stimulates cellular and DNA damage and is a major player in the formation of cancer cells and other chronic disease states.

These nano-sized titanium dioxide particles are able to slip through the gut lining and into the blood stream. They are also able to escape the immune system’s natural defenses and are able to float around in the blood stream and interfere with key biological functions.

A growing body of evidence supports that 500 nm sized titanium dioxide particles (at least 5 times larger than the size of nano-particles also found in food) can be absorbed through the gastrointestinal tract and stored in organs such as the liver and spleen. Smaller particles (ranging from 80 nm to 155 nm) had detectable damage to not only neighboring organs of the digestive tract, but also to the brain.4

Findings have shown that titanium dioxide exposure increases free radical stress, reactive oxygen species formation, and chronic inflammation throughout the body.4 This process may promote cell proliferation and deactivate normal cell apoptosis processes that control cancer cell development.

The presence of a protein known as PAD (peptidylarginine deiminase) appears to be induced when in the presence of titanium dioxide particles. PAD is present in cellular conditions exhibiting increased oxidative stress and inflammation.

Chemotherapy kills cancer patients faster than no treatment at all


Wishful thinking simply won’t deter from the fact that the cancer industry is just that: an industry. Doctors, drug companies, hospitals and other key stakeholders profit heavily each time a cancer patient submits to the conventional treatment model, which typically involves injecting chemotherapy poisons into the body, blasting it with ionizing radiation or cutting off body parts — or some barbaric combination of all three.

It might rub some people the wrong way to state this, especially those who’ve had to watch a loved one die from conventional cancer treatment, but each of these supposed treatments don’t actually work, in many cases. Little-known science, which the medical-industrial complex has made it a practice to ignore or cover up, reveals that, despite what the medical industry often claims, chemotherapy in particular just isn’t an effective cancer treatment.

Dr. Hardin B. Jones, a former professor of medical physics and physiology at the University of California, Berkeley, had been studying the lifespans of cancer patients for more than 25 years when he came to the conclusion that, despite popular belief, chemotherapy doesn’t work. He witnessed a multitude of cancer patients treated with the poison die horrific deaths, many of them meeting their fate much earlier than other patients who chose no treatment at all.

After investigating this further, Dr. Jones found that cancer patients who underwent chemotherapy actually died more quickly, in most cases, than those who followed their doctors’ recommendations by getting the treatment. A few number-crunching efforts later and Dr. Jones exposed a fact that the conventional cancer industry doesn’t want the world to know about its multi-billion-dollar cash cow.

Stop Forced Vaccinations


The National Socialist Roots Of Compulsory Vaccination

By Attorney Jonathan Emord

Legislators in thirteen states have introduced bills that would severely constrict or eliminate exemptions from compulsory vaccination, with the intended aim of coercing, cajoling, or forcing those who have not been vaccinated to become so. Those states are California (SB 277); Illinois (SB 1410); Maine (LD 606); Maryland (HB 687); Minnesota (SF 380 and HF 393); New Jersey (S 1147 and A351); New Mexico (HB 522); Oregon (SB 442); Pennsylvania; Rhode Island (S381); Texas (SB 1114; SB 538; HB 2006); Vermont (H212; S87); and Washington (HB 2009).

Amidst hysteria arising from a relatively small number of cases of measles (some 600 last year and some 150 this year), law makers would take away everyone’s rights to liberty and personal autonomy.


Santa Monica residents rally against forced vaccination



stop forced vaccinations

The sad reality is we’ve all been lied to by the US government when it comes to the safety and effectiveness of vaccinations. Vaccines are medical procedures that have little effectiveness with serious known risks, including death. They also contain known carcinogens such as aluminum, formaldehyde, mercury and other toxins.

Fungal Infections

fungal infection

During the summer, the feet sweat more than they usually do, so there is a bigger chance to develop a fungal infection in the area surrounding the fingers. Therefore, it is for the best to be barefoot as much as you can, take care about the hygiene of the feet and if you experience problems with the abovementioned infections, you should follow these advices:

Hydrogen peroxide

Hydrogen peroxide is an ideal tool for destroying bacteria and fungi, so if you soak your feet in a mixture from this compound and water, you can kill the unpleasant fungal infection and prevent its spreading. Add around 100 milliliters of 3% hydrogen peroxide in one liter of distillated water and soak your feet every morning and night for 20 minutes.

Sodium bicarbonate

It is recommended to avoid nylon socks as well as shoes with synthetic insole. Walk barefoot as much as you can. However, if you have to wear closed shoes, destroy all the potential bacteria in them by making a refreshing combination from cold water and sodium bicarbonate (1:3).

Pilling from corn starch

Starch is excellent in absorbing the moisture which makes it a great ingredient for pastes that prevent the appearance of unpleasant bacteria and fungi. Mix half a teaspoon of corn starch with a little bit of warm water. Set the oven to 220 degrees and keep the mixture into the oven until it darkens. Rub this mixture onto your previously dried and clean feet, leave it for 1 minute to react and then wash them off with warm water.

Soak your feet in yogurt!

The yogurt contains live bacteria- acidophilus and therefore it is a great cure for feet infections which develop in the area between the fingers and the nails. The “friendly” microorganisms present in the yogurt kill the fungal infections. Moreover, besides soaking them in yogurt, you can simply rub yogurt all over them and leave the yogurt to dry. Then, just wash off with cold water.